Nonstructural protein (NS1) of human parvovirus B19 stimulates host innate immunity and blunts the exogenous type I interferon signaling in vitro

被引：12
作者：
Wu, Jianqin [1 ,2 ,3 ]
Chen, Xu [1 ,2 ,3 ]
Ye, Haiyan [1 ,2 ,3 ]
Yao, Min [1 ,2 ,3 ]
Li, Shilin [1 ,2 ,3 ]
Chen, Limin [1 ,2 ,3 ,4 ]
机构：
[1] Chinese Acad Med Sci, Inst Blood Transfus, Chengdu 610052, Sichuan, Peoples R China
[2] Peking Union Med Coll, Chengdu 610052, Sichuan, Peoples R China
[3] Prov Key Lab Transfus Transmitted Dis Sichuan Pro, Chengdu 610052, Peoples R China
[4] Univ Toronto, Univ Hlth Network, Toronto Gen Res Inst, Toronto, ON M5G 1L6, Canada
来源：
VIRUS RESEARCH | 2016年 / 222卷
关键词：
NS1; B19; virus; Type I IFN signaling; CELLS; ACTIVATION; INFECTION; APOPTOSIS; DNA;
D O I：
10.1016/j.virusres.2016.06.004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
B19 virus is a non-enveloped DNA virus and belongs to the family of parvoviridae. There are two large open reading frames (ORFs), nonstructural protein (NS1) and two capsid proteins (VP1 and VP2). Host innate immune responses form the first line of defense against many pathogen invasion. How B19 virus, especially its encoded viral proteins interacts with host innate immune system remains unknown. In this study we aim to investigate the effect of NS1 on the host innate immune response and exogenous type I IFN signaling. Here we found that the type I IFN can be stimulated by NS1. Interestingly, NS1 also plays an important role in inhibiting the exogenous type I IFN signaling at p-STAT1, ISRE and ISGs levels. We concluded that NS1 may play pivotal role in evading the host immune surveillance. Our data shed novel light on the pathogenesis of B19 viral infection and virus evasion strategies. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：48 / 52
页数：5
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