RP - HPLC method for the estimation of Tamsulosin Hydrochloride in Tablet Dosage Form

被引：13
|
作者：
Kumari, Richa [1 ]
Dash, P. P. [1 ]
Lal, V. K. [1 ]
Mishra, A. [2 ]
Murthy, P. N. [3 ]
机构：
[1] Sagar Inst Technol & Management, Barabanki 225001, India
[2] Integral Univ, Lucknow 201126, Uttar Pradesh, India
[3] Royal Coll Pharm & Hlth Sci, Berhampur 760002, Ganjam, India
来源：
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2010年 / 72卷 / 06期
关键词：
RP-HPLC; stability indicating; tamsulosin HCl; validation;
D O I：
10.4103/0250-474X.84596
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A rapid and sensitive reverse phase RP-HPLC method is proposed for the estimation of tamsulosin hydrochloride in tablets. Tamsulosin hydrochloride was chromatographed on a reverse phase C18 column with a mobile phase consisting of acetonitrile and water in the ratio of 50: 50 v/v. The mobile phase was pumped at a flow rate of 1.5 ml/min. The eluents were monitored at 214 nm. The retention time of the drug was 1.7 min. With this method, linearity was observed between area under curve and concentration of tamsulosin hydrochloride in the injected solution, in the range of 5 to 100 mu g/ml. The method was found to be applicable for analysis of the drug in tablets. The results were validated statistically.
引用
收藏
页码：785 / U120
页数：3
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