A practical multigram-scale method for the green synthesis of 5-substituted-1H-tetrazoles in deep eutectic solvent

被引：45

作者：

Xiong, Xingquan ^{[1
]}

Yi, Chao ^{[1
]}

Liao, Xu ^{[1
]}

Lai, Shilin ^{[1
]}

机构：

[1] Univ Huaqiao, Coll Mat Sci & Engn, Xiamen 361021, Peoples R China

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 05期

基金：

中国国家自然科学基金;

关键词：

5-Substituted-1H-tetrazoles; Aldehydes; One-pot synthesis; Deep eutectic solvent; Green chemistry; 5-SUBSTITUTED; 1H-TETRAZOLES; 3+2 CYCLOADDITION; RECYCLABLE CATALYST; EFFICIENT SYNTHESIS; REUSABLE CATALYST; N-ARYLATION; NITRILES; NANOPARTICLES; COMPLEX; HETEROCYCLES;

D O I：

10.1016/j.tetlet.2018.12.037

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 5-substituted-1H-tetrazoles have been efficiently synthesized in moderate to excellent yields (68-90%) under mild reaction conditions by combining aryl aldehydes, hydroxylamine hydrochloride with sodium azide in the presence of catalytic amount of Cu(OAc)(2) in deep eutectic solvent (DES). The new synthetic method has many advantages, such as high conversion, green reaction medium, easy work-up, low cost, and environment friendly. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：402 / 406

页数：5

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