The effects of fentanyl, oxycodone, and butorphanol on gastrointestinal function in patients undergoing laparoscopic hysterectomy: a prospective, double-blind, randomized controlled trial

被引:7
作者
Guo, Minna [1 ]
Liu, Shijiang [2 ]
Gao, Jian [3 ]
Han, Chuanbao [2 ]
Yang, Chun [2 ]
Liu, Cunming [2 ]
机构
[1] Naval Med Univ, Changhai Hosp, Fac Anesthesiol, Shanghai, Peoples R China
[2] Nanjing Med Univ, Affiliated Hosp 1, Dept Anesthesiol & Perioperat Med, Nanjing, Peoples R China
[3] Shanxi Med Univ, Sch Publ Hlth, Taiyuan, Peoples R China
关键词
Postoperative gastrointestinal tract dysfunction; Opioid receptor; Analgesia; CONTROLLED ANALGESIA; ABDOMINAL HYSTERECTOMY; GYNECOLOGICAL SURGERY; POSTOPERATIVE ILEUS; OPIOID RECEPTORS; MORPHINE; PAIN; MECHANISMS;
D O I
10.1186/s12871-022-01594-9
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background: Perioperative opioid use is associated with postoperative bowel dysfunction, which causes longer hospital stay and higher healthcare costs. This study aimed to investigate the effect of the equivalent doses of fentanyl, oxycodone, and butorphanol on bowel function in patients undergoing laparoscopic hysterectomy. Methods: In this randomized controlled trial, 135 patients undergoing laparoscopic hysterectomy received postoperative intravenous patient-controlled analgesia (IV-PCA) with fentanyl 8.3 pg/kg, butorphanol 0.16 mg/kg, and oxycodone 0.5 mg/kg (1: 20: 60), respectively. The primary outcome measure was the recovery of bowel function. We also evaluated and recorded the following nine indicators: pain score, sedation level, leukocyte count, percentage of neutrophils, plasma potassium levels, time to first ambulation, postoperative side effects, patients'satisfaction, and postoperative hospital length of stay. Results: The mean time to flatus was significantly prolonged in Group B (45.2 +/- 11.6 h) compared with Group F (33.1 +/- 11.2 h, P< 0.001) and Group O (36.2 +/- 10.9 h, P=0.001). The incidence of somnolence and dizziness prove higher in Group B (P < 0.001). No statistical difference was observed in the mean time to tolerate oral diet, time to defecation, analgesic outcome, satisfaction score, time to first ambulation, and postoperative hospital length of stay. Conclusions: Compared with fentanyl and oxycodone, butorphanol prolonged the recovery of bowel function with more severe somnolence and dizziness, suggesting that butorphanol is not well suitable for IV-PCA in patients undergoing laparoscopic hysterectomy.
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页数:8
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