DESIGNED MULTI FUNCTIONAL DRUGS TARGETING NEUROPROTECTION, NEURORESTORATION AND MITOCHONDRIAL BIOGENESIS VIA ACTIVATION OF HIF1α, SIRT1, PGC-1α AND TFAM

被引：0
|
作者：
Youdim, Moussa B. H. [1 ]
机构：
[1] Technion Rappaport Familty Fac Med, Eve Topf Ctr, Haifa, Israel
来源：
NEUROBIOLOGY OF AGING | 2014年 / 35卷
关键词：
Neuroprotection; Neurorestoration; Mitochondria biogenesis;
D O I：
10.1016/j.neurobiolaging.2014.01.129
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
引用
收藏
页码：S26 / S26
页数：1
相关论文
共 50 条
  • [1] Multi target anti Parkinson's disease drugs targeting mitochondrial biogenesis and neurorestoration via activation of and HIF, SIRT1, PGC-1α and Tfam
    Youdim, M. B. H.
    JOURNAL OF MOLECULAR NEUROSCIENCE, 2014, 53 : S132 - S133
  • [2] Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation
    Higashida, Kazuhiko
    Kim, Sang Hyun
    Jung, Su Ryun
    Asaka, Meiko
    Holloszy, John O.
    Han, Dong-Ho
    PLOS BIOLOGY, 2013, 11 (07):
  • [3] Perampanel Stimulates Mitochondrial Biogenesis in Neuronal Cells through Activation of the SIRT1/PGC-1α Signaling Pathway
    Jiang, Ying
    Li, Da
    Du, Zhiqiang
    Li, Jie
    Lu, Rongrong
    Zhou, Qin
    Wang, Qi
    Zhu, Haohao
    ACS CHEMICAL NEUROSCIENCE, 2021, 12 (02): : 323 - 329
  • [4] Resveratrol improved mitochondrial biogenesis by activating SIRT1/PGC-1α signal pathway in SAP
    Wu, Shu-kun
    Wang, Le
    Wang, Fang
    Zhang, Jiong
    SCIENTIFIC REPORTS, 2024, 14 (01):
  • [5] SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis
    Li, Yuming
    Xu, Shangcheng
    Li, Jing
    Zheng, Lu
    Feng, Min
    Wang, Xiaoya
    Han, Keqiang
    Pi, Huifeng
    Li, Min
    Huang, Xiaobing
    You, Nan
    Tian, Yewang
    Zuo, Guohua
    Li, Hongyan
    Zhao, Hongzhi
    Deng, Ping
    Yu, Zhengping
    Zhou, Zhou
    Liang, Ping
    ONCOTARGET, 2016, 7 (20) : 29255 - 29274
  • [6] SIRT1 Protects Dopaminergic Neurons in Parkinson's Disease Models via PGC-1α-Mediated Mitochondrial Biogenesis
    Chen, Yu
    Jiang, Yuhui
    Yang, Yinuo
    Huang, Xinzhong
    Sun, Cheng
    NEUROTOXICITY RESEARCH, 2021, 39 (05) : 1393 - 1404
  • [7] Effect of Resveratrol on Mitochondrial Biogenesis and Muscle Fiber Type Transformation in Bovine Myotubes via SIRT1/PGC-1α
    Zhang J.
    Dong P.
    Zuo H.
    Liang R.
    Mao Y.
    Zhang Y.
    Yang X.
    Luo X.
    Zhu L.
    Shipin Kexue/Food Science, 2024, 45 (04): : 1 - 9
  • [8] SIRT1 Protects Dopaminergic Neurons in Parkinson’s Disease Models via PGC-1α-Mediated Mitochondrial Biogenesis
    Yu Chen
    Yuhui Jiang
    Yinuo Yang
    Xinzhong Huang
    Cheng Sun
    Neurotoxicity Research, 2021, 39 : 1393 - 1404
  • [9] Pharmacological approaches to enhance mitochondrial biogenesis: focus on PGC-1Α, AMPK, and SIRT1 in cellular health
    Palabiyik, Ahmet Alperen
    Palabiyik, Esra
    MOLECULAR BIOLOGY REPORTS, 2025, 52 (01)
  • [10] SIRT1 Regulates Mitochondrial Damage in N2a Cells Treated with the Prion Protein Fragment 106-126 via PGC-1α-TFAM-Mediated Mitochondrial Biogenesis
    Zhao, Mengyang
    Li, Jie
    Li, Zhiping
    Yang, Dongming
    Wang, Dongdong
    Sun, Zhixin
    Wen, Pei
    Gou, Fengting
    Dai, Yuexin
    Ji, Yilan
    Li, Wen
    Zhao, Deming
    Yang, Lifeng
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (17)
12345