An Improved Route to Purin-6-yl Magnesium Halides by Metal-Halogen Exchange in Dichloromethane

被引：9

作者：

Gordon, Malcolm R. ^{[1
]}

Lindell, Stephen D. ^{[1
]}

Richards, Daniel ^{[1
]}

机构：

[1] Bayer AG, Crop Sci Div, Ind Pk Hochst, D-65926 Frankfurt, Germany

来源：

SYNLETT | 2018年 / 29卷 / 04期

关键词：

nucleobases; purin-6-yl magnesium halides; Grignard; dichloromethane; carbinols; PURINES; HETEROCYCLES; DERIVATIVES; ALDEHYDES; IMIDAZOLE; REAGENTS;

D O I：

10.1055/s-0036-1591727

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of a solution of 9-benzyl or 9-phenyl 6-iodopurine in dichloromethane with an ethereal solution of ethylmagnesium bromide at ambient temperature generates the corresponding purin-6-yl magnesium halides which react with aldehydes to give carbinols in 55-80% yield. Performing the same procedure with THF as solvent gave carbinols in much lower yields (<= 15%).

引用

页码：473 / 476

页数：4

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