Photo-responsive degradable hollow mesoporous organosilica nanoplatforms for drug delivery

被引：39

作者：

Fan, Jie ^{[1
]}

Zhang, Zhipeng ^{[1
]}

Wang, Yaru ^{[1
]}

Lin, Shiting ^{[1
]}

Yang, Shun ^{[1
]}

机构：

[1] Jiangsu Normal Univ, Sch Chem & Chem Engn, Xuzhou 221116, Jiangsu, Peoples R China

来源：

JOURNAL OF NANOBIOTECHNOLOGY | 2020年 / 18卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Organosilica; Photo-responsive degradation; Drug delivery; Graphene oxide quantum dots; Hollow mesoporous materials; CO-GLYCOLIDE MICROPARTICLES; ENHANCED PERMEABILITY; PARTICLE-SIZE; NANOPARTICLES; POLYLACTIDE; NANOCARRIERS; CHEMOTHERAPY; THERAPY; RELEASE; AGENTS;

D O I：

10.1186/s12951-020-00642-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background Stimulus-responsive degradable mesoporous organosilica nanoparticles (MONs) have shown great promise as drug carriers via enhancing the efficiency of drug delivery and accelerating the degradation of nanocarriers. However, it remains a great challenge to develop novel light-enabled spatial and temporal degradable MONs with both superior responsiveness for efficient anti-cancer drug delivery and safe exocytosis. Results We report a novel photo-responsive degradable hollow mesoporous organosilica nanoplatform (HMONs@GOQD). The platform is based on organosilica nanoparticles (HMONs) containing singlet oxygen (O-1(2))-responsive bridged organoalkoxysilanes and wrapped graphene oxide quantum dots (GOQDs). The unique hollow mesoporous structure of the HMONs guarantees an excellent drug loading and release profile. During light irradiation,(1)O(2)produced by the GOQDs leads to the degradation of the organosilica nanoparticles, resulting in enhanced local drug release. Conclusions We carried out in vitro and in vivo experiments using DOX as a model drug; DOX-HMONs@GOQDs exhibited high biocompatibility, accelerated degradation, and superior therapeutic efficacy during light irradiation, indicating a promising platform for clinical cancer therapy.

引用

页数：14

共 66 条

[1] 1,9-Dialkoxyanthracene as a 1O2-Sensitive Linker [J].

Arian, Dumitru ;

Kovbasyuk, Larisa ;

Mokhir, Andriy .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (11) :3972-3980

[2] Biodegradable poly(ε-caprolactone) nanoparticles for tumor-targeted delivery of tamoxifen [J].

Chawla, JS ;

Amiji, MM .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 249 (1-2) :127-138

[3] Fabrication of multifunctional triple-responsive platform based on CuS-capped periodic mesoporous organosilica nanoparticles for chemo-photothermal therapy [J].

Cheng, Xiangyang ;

Li, Dejian ;

Lin, Aiqi ;

Xu, Jun ;

Wu, Liang ;

Gu, Huijie ;

Huang, Zhongyue ;

Liu, Jiangyi ;

Zhang, Yiming ;

Yin, Xiaofan .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2018, 13 :3661-3677

[4] Renal clearance of quantum dots [J].

Choi, Hak Soo ;

Liu, Wenhao ;

Misra, Preeti ;

Tanaka, Eiichi ;

Zimmer, John P. ;

Ipe, Binil Itty ;

Bawendi, Moungi G. ;

Frangioni, John V. .

NATURE BIOTECHNOLOGY, 2007, 25 (10) :1165-1170

[5] Mechanised nanoparticles for drug delivery [J].

Coti, Karla K. ;

Belowich, Matthew E. ;

Liong, Monty ;

Ambrogio, Michael W. ;

Lau, Yuen A. ;

Khatib, Hussam A. ;

Zink, Jeffrey I. ;

Khashab, Niveen M. ;

Stoddart, J. Fraser .

NANOSCALE, 2009, 1 (01) :16-39

[6] Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles [J].

Croissant, Jonas G. ;

Fatieiev, Yevhen ;

Khashab, Niveen M. .

ADVANCED MATERIALS, 2017, 29 (09)

[7] Hybrid Organic-Inorganic Polyoxometalate Compounds: From Structural Diversity to Applications [J].

Dolbecq, Anne ;

Dumas, Eddy ;

Mayer, Cedric R. ;

Mialane, Pierre .

CHEMICAL REVIEWS, 2010, 110 (10) :6009-6048

[8] Influence of particle size and dissolution conditions on the degradation properties of polylactide-co-glycolide particles [J].

Dunne, M ;

Corrigan, OI ;

Ramtoola, Z .

BIOMATERIALS, 2000, 21 (16) :1659-1668

[9] Biodegradable and Renal Clearable Inorganic Nanoparticles [J].

Ehlerding, Emily B. ;

Chen, Feng ;

Cai, Weibo .

ADVANCED SCIENCE, 2016, 3 (02)

[10] Enzymatically degradable hybrid organic-inorganic bridged silsesquioxane nanoparticles for in vitro imaging [J].

Fatieiev, Y. ;

Croissant, J. G. ;

Julfakyan, K. ;

Deng, L. ;

Anjum, D. H. ;

Gurinov, A. ;

Khashab, N. M. .

NANOSCALE, 2015, 7 (37) :15046-15050

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