Bioactivity and Therapeutic Potential of Kaempferol and Quercetin: New Insights for Plant and Human Health

被引：136
作者：
Jan, Rahmatullah [1 ,2 ]
Khan, Murtaza [3 ]
Asaf, Sajjad [4 ]
Lubna [5 ]
Asif, Saleem [1 ]
Kim, Kyung-Min [1 ,2 ]
机构：
[1] Kyungpook Natl Univ, Grad Sch, Dept Appl Biosci, Daegu 41566, South Korea
[2] Kyungpook Natl Univ, Coastal Agr Res Inst, Dept Appl Biosci, Daegu 41566, South Korea
[3] Yeungnam Univ, Dept Hort & Life Sci, Gyongsan 38541, South Korea
[4] Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman
[5] Abdul Wali Khan Univ Mardan, Dept Bot, Mardan 23200, Pakistan
来源：
PLANTS-BASEL | 2022年 / 11卷 / 19期
关键词：
kaempferol; quercetin; therapeutic; bioavailability; bioactivity; antioxidant; CORONARY-HEART-DISEASE; AUXIN TRANSPORT; FLAVONOID GLYCOSIDES; DIETARY FLAVONOIDS; STRESS TOLERANCE; SMALL-INTESTINE; SALICYLIC-ACID; BLOOD-PRESSURE; RISK-FACTORS; IN-VITRO;
D O I：
10.3390/plants11192623
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Plant secondary metabolites, especially flavonoids, are major metabolites widely found in plants that play several key roles in plant defence and signalling in response to stress conditions. The most studied among these flavonoids are kaempferol and quercetin due to their anti-oxidative potential and their key roles in the defence system, making them more critical for plant adaptation in stress environments. Kaempferol and quercetin in plants have great therapeutic potential for human health. Despite being well-studied, some of their functional aspects regarding plants and human health need further evaluation. This review summarizes the emerging potential of kaempferol and quercetin in terms of antimicrobial activity, bioavailability and bioactivity in the human body as well as in the regulation of plant defence in response to stresses and as a signalling molecule in terms of hormonal modulation under stress conditions. We also evaluated the safe use of both metabolites in the pharmaceutical industry.
引用
收藏
页数：18
相关论文
共 50 条
[31]   New Insights into Anticarcinogenic Properties of Adiponectin: A Potential Therapeutic Approach in Breast Cancer? [J].
Delort, Laetitia ;
Jarde, Thierry ;
Dubois, Virginie ;
Vasson, Marie-Paule ;
Caldefie-Chezet, Florence .
ADIPONECTIN, 2012, 90 :397-417
[32]   Therapeutic Potential of Quercetin-Loaded Nanoemulsion against Experimental Visceral Leishmaniasis: In Vitro/Ex Vivo Studies and Mechanistic Insights [J].
Das, Sabya Sachi ;
Dubey, Amit Kumar ;
Verma, Priya Ranjan Prasad ;
Singh, Sandeep Kumar ;
Singh, Shubhankar Kumar .
MOLECULAR PHARMACEUTICS, 2022, 19 (09) :3367-3384
[33]   Resources for Human Health from the Plant Kingdom: The Potential Role of the Flavonoid Apigenin in Cancer Counteraction [J].
Fossatelli, Laura ;
Maroccia, Zaira ;
Fiorentini, Carla ;
Bonucci, Massimo .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (01)
[34]   Unleashed Treasures of Solanaceae: Mechanistic Insights into Phytochemicals with Therapeutic Potential for Combatting Human Diseases [J].
Jan, Saima ;
Iram, Sana ;
Bashir, Ommer ;
Shah, Sheezma Nazir ;
Kamal, Mohammad Azhar ;
Rahman, Safikur ;
Kim, Jihoe ;
Jan, Arif Tasleem .
PLANTS-BASEL, 2024, 13 (05)
[35]   Quercetin: total-scale literature landscape analysis of a valuable nutraceutical with numerous potential applications in the promotion of human and animal health - a review [J].
Yeung, Andy Wai Kan ;
Choudhary, Neeraj ;
Tewari, Devesh ;
El-Demerdash, Amr ;
Horbanczuk, Olaf K. ;
Das, Niranjan ;
Pirgozliev, Vasil ;
Lucarini, Massimo ;
Durazzo, Alessandra ;
Souto, Eliana B. ;
Santini, Antonello ;
Devkota, Hari Prasad ;
Uddin, Md. Sahab ;
Echeverria, Javier ;
Wang, Dongdong ;
Gan, Ren-You ;
Brncic, Mladen ;
Kalfin, Reni E. ;
Tzvetkov, Nikolay T. ;
Jozwik, Artur ;
Solka, Magdalena ;
Strzalkowska, Nina ;
Horbanczuk, Jaroslaw Olav ;
Atanasov, Atanas G. .
ANIMAL SCIENCE PAPERS AND REPORTS, 2021, 39 (03) :199-212
[36]   Food-derived glycopeptides: structural insights, glycosylation-driven bioactivity, and translational potential in health and functional applications [J].
Huang, Qianqian ;
Song, Chunyong ;
Chen, Zhongqin ;
Tan, Mingtang ;
Zheng, Huina ;
Lin, Haisheng ;
Gao, Jialong ;
Qin, Xiaoming ;
Cao, Wenhong .
TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2025, 161
[37]   The Intestinal Environment in Health and Disease - Recent Insights on the Potential of Intestinal Bacteria to Influence Human Health [J].
Possemiers, Sam ;
Grootaert, Charlotte ;
Vermeiren, Joan ;
Gross, Gabriele ;
Marzorati, Massimo ;
Verstraete, Willy ;
Van de Wiele, Tom .
CURRENT PHARMACEUTICAL DESIGN, 2009, 15 (18) :2051-2065
[38]   Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets [J].
Zhang, Zenglei ;
Zhao, Lin ;
Zhou, Xingyu ;
Meng, Xu ;
Zhou, Xianliang .
FRONTIERS IN IMMUNOLOGY, 2023, 13
[39]   Therapeutic Potential of Phenolic Compounds in Medicinal Plants-Natural Health Products for Human Health [J].
Sun, Wenli ;
Shahrajabian, Mohamad Hesam .
MOLECULES, 2023, 28 (04)
[40]   Mechanistic insights into anti-inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis [J].
Yuandani ;
Jantan, Ibrahim ;
Salim, Emil ;
Septama, Abdi Wira ;
Rullah, Kamal ;
Nainu, Firzan ;
Aluwi, Mohd Fadhlizil Fasihi Mohd ;
Bin Emran, Talhah ;
Roney, Miah ;
Khairunnisa, Nur Aini ;
Nasution, Halimah Raina ;
As'ad, Muh. Fadhil ;
Shamsudin, Nur Farisya ;
Abdullah, Maryam Aisyah ;
Marwa Rani, Haya Luthfiyyah ;
Al Chaira, Diany Mahabbah ;
Aulia, Nabila .
PHYTOTHERAPY RESEARCH, 2024, 38 (06) :2931-2961
12345