The μ-opioid receptor nonsynonymous variant 118A>G is associated with prolonged abstinence from heroin without agonist treatment

被引：13

作者：

Levran, Orna ^{[1
]}

Peles, Einat ^{[2
,3
]}

Randesi, Matthew ^{[1
]}

da Rosa, Joel Correa ^{[4
]}

Adelson, Miriam ^{[1
,2
,5
]}

Kreek, Mary Jeanne ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10065 USA

[2] Tel Aviv Elias Sourasky Med Ctr, Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, 1 Henrietta Szold St, IL-64924 Tel Aviv, Israel

[3] Tel Aviv Univ, Sackler Fac Med, IL-69978 Ramat Aviv, Israel

[4] Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10065 USA

[5] Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Las Vegas, NV 89169 USA

来源：

PHARMACOGENOMICS | 2017年 / 18卷 / 15期

关键词：

abstinence; heroin addiction; HPA axis; opioids; rs1799971; stress; mu-opioid receptor; SINGLE-NUCLEOTIDE POLYMORPHISM; CORTISOL RESPONSE; GENE POLYMORPHISM; OPIATE ADDICTION; OPRM1; A118G; METAANALYSIS; DEPENDENCE; HAPLOTYPE; STRESS;

D O I：

10.2217/pgs-2017-0092

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: This study assesses whether opioid-related gene variants contribute to reduced vulnerability to relapse to heroin in persons who are not treated with mu-opioid receptor agonist. Methods: Genotypes of 71 SNPs, in nine genes, were analyzed for association with long-term abstinence in former heroindependents of European/Middle Eastern ancestry, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 922). Results: The functional OPRM1 nonsynonymous SNP rs1799971 (118A> G) showed significant association with long-term abstinence (Ppermutation = 0.03, dominant model, OR: 2.2; 95% CI: 1.5-3.3). Conclusion: Since the stress axis is regulated in part by mu-endorphin, this functional OPRM1 SNP may blunt the endogenous stress response and contribute to reduced vulnerability for relapse.

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收藏

页码：1393 / 1400

页数：8

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