Identifying structure-function relationships in four-helix bundle cytokines: Towards de novo mimetics design

被引:41
作者
Chaiken, IM
Williams, WV
机构
关键词
D O I
10.1016/0167-7799(96)10050-0
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Many cytokines (growth-factor proteins) are constructed from a common four-helix bundle structural framework. Rapid advances have been made in relating the structure and function of a growing number of four-helix bundle cytokines. This understanding opens the way to design de novo mimetics through such strategies as cytokine hybrids, structure-excerpted scaffolds and contact residue topology mimics. These may provide leads for agonists and antagonists of cell growth and differentiation.
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页码:369 / 375
页数:7
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