Zinc(II)-Catalyzed Synthesis of Propargylamines by Coupling Aldimines and Ketimines with Alkynes

被引：19

作者：

Shehzadi, Syeda Aaliya ^{[1
]}

Saeed, Aamer ^{[2
]}

Lemiere, Filip ^{[3
,4
]}

Maes, Bert U. W. ^{[1
]}

Tehrani, Kourosch Abbaspour ^{[1
]}

机构：

[1] Univ Antwerp, Dept Chem, Organ Synth, Groenenborgerlaan 171, B-2020 Antwerp, Belgium

[2] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan

[3] Univ Antwerp, Biomol & Analyt Mass Spectrometry, B-2020 Antwerp, Belgium

[4] Univ Antwerp, Dept Chem, Ctr Prote, B-2020 Antwerp, Belgium

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 01期

关键词：

C-C coupling; Alkynes; Amines; Schiff bases; Zinc; SELECTIVE SYNTHESIS; TERMINAL ALKYNES; SECONDARY-AMINES; EN-ROUTE; HYDROAMINATION; ALKYNYLATION; DERIVATIVES; EFFICIENT; CATALYST; NANOPARTICLES;

D O I：

10.1002/ejoc.201701567

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Zn-II-catalyzed reaction between imines, which were derived from unactivated aldehydes or ketones and primary amines or -amino acid esters, and terminal alkynes has led to the rapid and efficient formation of tri- and tetrasubstituted propargylamines (from aldimines and ketimines, respectively) in good to excellent yields. No additives or extra Lewis acid reagents were required for the imine-alkyne coupling reaction.

引用

页码：78 / 88

页数：11

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