A new polymer-supported reagent for the Fmoc-protection of acids

被引：31

作者：

Chinchilla, R ^{[1
]}

Dodsworth, DJ ^{[1
]}

Nájera, C ^{[1
]}

Soriano, JM ^{[1
]}

机构：

[1] Univ Alicante, Dept Quim Organ, E-03080 Alicante, Spain

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 43期

关键词：

amino acids; protecting groups; polymers;

D O I：

10.1016/S0040-4039(01)01615-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new polymer-supported Fmoc-OSu (Fmoc-P-OSu) has been prepared from polymer-bound N-hydroxysuccinimide (P-HOSu), and used as a solid-supported reagent for the Fmoc-protection of amino groups. The residual P-HOSu generated after the protection reaction can be separated by simple filtration and reused. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：7579 / 7581

页数：3

共 30 条

[1]

ATHERTON E, 1987, PEPTIDES ANAL SYNTHE, V9, P1

[2] A ROMPGEL-supported N-hydroxysuccinimide:: A host of acylations with minimal purification [J].

Barrett, AGM ;

Cramp, SM ;

Roberts, RS ;

Zecri, FJ .

ORGANIC LETTERS, 2000, 2 (03) :261-264

[3]

Bodanszky M., 1984, PRACTICE PEPTIDE SYN

[4]

Brown AR, 1998, SYNLETT, P817

[5]

BROWN AR, 1999, CHEM REV, V99, P1549

[6] Recent developments in solid-phase organic synthesis [J].

Brown, R .

CONTEMPORARY ORGANIC SYNTHESIS, 1997, 4 (03) :216-237

[7] 9-FLUORENYLMETHOXYCARBONYL AMINO-PROTECTING GROUP [J].

CARPINO, LA ;

HAN, GY .

JOURNAL OF ORGANIC CHEMISTRY, 1972, 37 (22) :3404-&

[8] ((9-FLUORENYLMETHYL)OXY)CARBONYL AMINO-ACID CHLORIDES IN SOLID-PHASE PEPTIDE-SYNTHESIS [J].

CARPINO, LA ;

CHAO, HG ;

BEYERMANN, M ;

BIENERT, M .

JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (08) :2635-2642

[9] THE 9-FLUORENYLMETHYLOXYCARBONYL FAMILY OF BASE-SENSITIVE AMINO-PROTECTING GROUPS [J].

CARPINO, LA .

ACCOUNTS OF CHEMICAL RESEARCH, 1987, 20 (11) :401-407

[10] Polymer-bound N-hydroxysuccinimide as a solid-supported additive for DCC-mediated peptide synthesis [J].

Chinchilla, R ;

Dodsworth, DJ ;

Nájera, C ;

Soriano, JM .

TETRAHEDRON LETTERS, 2001, 42 (27) :4487-4489

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