Neuroendocrine Regulation of Food Intake

被引：18
作者：
Hagan, Scott [1 ]
Niswender, Kevin D. [1 ]
机构：
[1] Vanderbilt Univ, Sch Med, Div Diabet Endocrinol & Metab, Tennessee Valley Healthcare Syst,Dept Med, Nashville, TN 37232 USA
来源：
PEDIATRIC BLOOD & CANCER | 2012年 / 58卷 / 01期
关键词：
energy homeostasis; food intake; obesity; CONGENITAL LEPTIN DEFICIENCY; NERVOUS-SYSTEM CONTROL; BASAL INSULIN LEVELS; ENERGY HOMEOSTASIS; RECOMBINANT LEPTIN; BODY-WEIGHT; OBESITY; RATS; CHOLECYSTOKININ; SIGNALS;
D O I：
10.1002/pbc.23376
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Despite a global obesity epidemic suggesting that human physiology is unable to prevent unhealthy gains in body weight, ample evidence indicates that weight can be tightly regulated. Food intake regulation is complex and in this article we will present a basic endocrine feedback loop model of energy homeostasis. Next, integration of long-term regulation with short-term, meal specific regulation and satiety will be discussed. Finally, the role of adiposity signals in modulation of food reward will be highlighted. A basic understanding of the structure-function of these systems will inform the challenges of clinical care for those with disorders of energy balance. Pediatr Blood Cancer 2012; 58: 149-153. (C) 2011 Wiley Periodicals, Inc.
引用
收藏
页码：149 / 153
页数：5
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