Alisporivir Has Limited Antiviral Effects Against Ebola Virus Strains Makona and Mayinga

被引：6

作者：

Chiramel, Abhilash I. ^{[1
]}

Banadyga, Logan ^{[1
]}

Dougherty, Jonathan D. ^{[1
]}

Falzarano, Darryl ^{[1
,3
]}

Martellaro, Cynthia ^{[1
]}

Brees, Dominique ^{[4
]}

Taylor, R. Travis ^{[1
,2
]}

Ebihara, Hideki ^{[1
]}

Best, Sonja M. ^{[1
]}

机构：

[1] NIAID, Lab Virol, NIH, Rocky Mt Labs, Hamilton, MT USA

[2] Univ Toledo, Coll Med, Dept Med Microbiol & Immunol, Hlth Sci Campus, Toledo, OH 43606 USA

[3] Univ Saskatchewan, Vaccine & Infect Dis Org, Int Vaccine Ctr, Saskatoon, SK, Canada

[4] Novartis Pharmaceut, Basel, Switzerland

来源：

JOURNAL OF INFECTIOUS DISEASES | 2016年 / 214卷

基金：

美国国家卫生研究院;

关键词：

alisporivir; Ebola virus; cyclophilin A; antivirals; flavivirus; CYCLOSPORINE; REPLICATION; CYCLOPHILINS; COMBINATION; INFECTION;

D O I：

10.1093/infdis/jiw241

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antiviral therapeutics with existing clinical safety profiles would be highly desirable in an outbreak situation, such as the 2013-2016 emergence of Ebola virus (EBOV) in West Africa. Although, the World Health Organization declared the end of the outbreak early 2016, sporadic cases of EBOV infection have since been reported. Alisporivir is the most clinically advanced broad-spectrum antiviral that functions by targeting a host protein, cyclophilin A (CypA). A modest antiviral effect of alisporivir against contemporary (Makona) but not historical (Mayinga) EBOV strains was observed in tissue culture. However, this effect was not comparable to observations for an alisporivir-susceptible virus, the flavivirus tick-borne encephalitis virus. Thus, EBOV does not depend on (CypA) for replication, in contrast to many other viruses pathogenic to humans.

引用

页码：S355 / S359

页数：5

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