Ezogabine: A New Angle On Potassium Gates

被引：14
作者：
Faught, Edward [1 ]
机构：
[1] Emory Univ, Atlanta, GA 30322 USA
来源：
EPILEPSY CURRENTS | 2011年 / 11卷 / 03期
关键词：
ANTICONVULSANT RETIGABINE; EPILEPSY; SEIZURES; CHANNEL; D-23129; MODEL; EFFICACY; BINDING; SAFETY; KCNQ2;
D O I：
10.5698/1535-7511-11.3.75
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Ezogabine is a new drug for adjunctive therapy of partial-onset seizures with a novel mechanism of action. As a potassium-channel facilitator, it promotes membrane repolarization and thus opposes rapid repetitive discharges. Side effects are typical for antiepileptic drugs and the safety profile is good. Occasional instances of urinary difficulty may require surveillance.
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收藏
页码：75 / 78
页数：4
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