Polyurethane with tethered copper(II)-cyclen complex:: Preparation, characterization and catalytic generation of nitric oxide from S-nitrosothiols

被引：63
作者：
Hwang, Sangyeul [1 ]
Meyerhoff, Mark E. [1 ]
机构：
[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
来源：
BIOMATERIALS | 2008年 / 29卷 / 16期
关键词：
copper; hemocompatibility; nitric oxide; polyurethane; S-nitrosothiols;
D O I：
10.1016/j.biomaterials.2008.02.004
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The preparation and characterization of a commercial biomedical-grade polyurethane (Tecophilic (R), SP-93A-100) material possessing covalently linked copper(II)-cyclen moieties as a nitric oxide (NO) generating polymer are described. Chemiluminescence NO measurements demonstrate that the prepared polymer can decompose endogenous S-nitrosothiols (RSNOs) such as S-nitrosoglutathione and S-nitrosocysteine to NO in the presence of thiol reducing agents (RSHs; e.g., glutathione and cysteine) at physiological pH. Since such RSNO and RSH species already exist in blood, the proposed polymer is capable of spontaneously generating NO when in contact with fresh blood. This is demonstrated by utilizing the polymer as an outer coating at the distal end of an amperometric NO sensor to create a device that generates response toward the RSNO species in the blood. This polymer possesses the combined benefits of a commercial biomedical-grade polyurethane with the ability to generate biologically active NO when in contact with blood, and thus may serve as a useful coating to improve the hemocompatibility of various medical devices. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2443 / 2452
页数：10
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