Gene therapy progress and prospects: Viral trafficking during infection

被引：32

作者：

Campbell, EM ^{[1
]}

Hope, TJ ^{[1
]}

机构：

[1] Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA

来源：

GENE THERAPY | 2005年 / 12卷 / 18期

关键词：

virus; infection; trafficking; HIV; HSV; adenovirus; cytoskeleton; nuclear import;

D O I：

10.1038/sj.gt.3302585

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The intracellular steps involved in viral infection, namely cytoplasmic trafficking and nuclear import, are critical events in the viral life cycle that have lagged behind other areas of viral research. This review examines recent advances in our understanding of these steps for viruses commonly employed as viral gene delivery vectors. Steps governing the cytoplasmic trafficking and nuclear import of Herpes Simplex virus, Human Immunodeficiency virus and Adenovirus are reviewed in this article.

引用

页码：1353 / 1359

页数：7

共 34 条

[21] Herpes simplex virus type 1 entry into host cells: Reconstitution of capsid binding and uncoating at the nuclear pore complex in vitro [J].

Ojala, PM ;

Sodeik, B ;

Ebersold, MW ;

Kutay, U ;

Helenius, A .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (13) :4922-4931

[22] Nuclear import of the pre-integration complex (PIC): The Achilles heel of HIV ? [J].

Piller, SC ;

Caly, L ;

Jans, DA .

CURRENT DRUG TARGETS, 2003, 4 (05) :409-429

[23] Cellular motility driven by assembly and disassembly of actin filaments [J].

Pollard, TD ;

Borisy, GG .

CELL, 2003, 112 (04) :453-465

[24] Ultrastructural localization of the herpes simplex virus type 1 UL31, UL34, and US3 proteins suggests specific roles in primary envelopment and egress of nucleocapsids [J].

Reynolds, AE ;

Wills, EG ;

Roller, RJ ;

Ryckman, BJ ;

Baines, JD .

JOURNAL OF VIROLOGY, 2002, 76 (17) :8939-8952

[25] Nuclear import adenovirus DNA in vitro involves the nuclear protein import pathway and hsc70 [J].

Saphire, ACS ;

Guan, TL ;

Schirmer, EC ;

Nemerow, GR ;

Gerace, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (06) :4298-4304

[26] Dynactin [J].

Schroer, TA .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2004, 20 :759-779

[27] Real-time single-molecule imaging of the infection pathway of an adeno-associated virus [J].

Seisenberger, G ;

Ried, MU ;

Endress, T ;

Büning, H ;

Hallek, M ;

Bräuchle, C .

SCIENCE, 2001, 294 (5548) :1929-1932

[28] Microtubule-mediated transport of incoming herpes simplex virus 1 capsids to the nucleus [J].

Sodeik, B ;

Ebersold, MW ;

Helenius, A .

JOURNAL OF CELL BIOLOGY, 1997, 136 (05) :1007-1021

[29] Microtubule-dependent plus- and minus end-directed motilities are competing processes for nuclear targeting of adenovirus [J].

Suomalainen, M ;

Nakano, MY ;

Keller, S ;

Boucke, K ;

Stidwill, RP ;

Greber, UF .

JOURNAL OF CELL BIOLOGY, 1999, 144 (04) :657-672

[30] Adenovirus-activated PKA and p38/MAPK pathways boost microtubule-mediated nuclear targeting of virus [J].

Suomalainen, M ;

Nakano, MY ;

Boucke, K ;

Keller, S ;

Greber, UF .

EMBO JOURNAL, 2001, 20 (06) :1310-1319

← 1 2 3 4 →