Is the Correlation between Salivary Cortisol and Serum Cortisol Reliable Enough to Enable Use of Salivary Cortisol Levels in Preterm Infants?

被引:0
|
作者
Amin, Harish [1 ]
Wynne-Edwards, Katherine [2 ]
Amin, Parthiv [3 ]
Zhou, Ruokun [2 ]
Sundaram, Arun [1 ]
Martinez-Soto, Tania [4 ]
Pacaud, Daniele [4 ]
机构
[1] Univ Calgary, Sect Neonatol, Dept Pediat, Calgary, AB, Canada
[2] Univ Calgary, Vet Med & Hotchkiss Brain Inst, Comparat Biol & Expt Med, Calgary, AB, Canada
[3] Univ Calgary, Cumming Sch Med, UME, Calgary, AB, Canada
[4] Univ Calgary, Sect Pediat Endocrinol, Dept Pediat, Calgary, AB, Canada
关键词
salivary cortisol; serum cortisol; saliva collection; preterm infants; LONGITUDINAL EVALUATION; ADRENAL INSUFFICIENCY; CIRCADIAN-RHYTHM; TERM; PLASMA;
D O I
10.1055/s-0037-1603345
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Background Newborn premature infants are susceptible to development of relative adrenal insufficiency following transition from fetal to extrauterine life. However, the best diagnostic test for adrenal insufficiency in neonates has yet to be developed. Objectives and Methods The aim of this study was (1) to assess the feasibility of obtaining sufficient saliva sample to allow measurement of cortisol by liquid chromatography coupled to tandem mass spectrometry and (2) to assess the correlation, if any, between salivary and serum cortisol in preterm infants of <= 32 weeks' gestational age at birth. Results Samples for 230 paired serum and saliva cortisol levels from 90 preterm infants were analyzed. 87.5% of samples collected had sufficient salivary volumes for measurement. Despite being statistically significant (p < 0.0001), the correlation (Spearman r = 0.674) between serum and salivary cortisol was not strong. Conclusion Salivary free cortisol measurement is feasible but cannot be used to accurately reflect serum total cortisol. Further studies comparing salivary free cortisol to serum free cortisol and establishing normative data are needed before salivary cortisol can be used for diagnostic purposes.
引用
收藏
页码:1302 / 1305
页数:4
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