Cytotoxic activity of some Asarum plants

被引：18

作者：

Cai, Shao-Qing ^{[1
]}

Yu, Jie ^{[1
]}

Wang, Xuan ^{[1
]}

Wang, Rui-Qing ^{[1
]}

Ran, Fu-Xiang ^{[1
]}

Shang, Ming-Ying ^{[1
]}

Cui, Jing-Rong ^{[1
]}

Komatsu, Katsuko ^{[2
]}

Namba, Tsuneo ^{[2
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biominet Drugs, Beijing 100083, Peoples R China

[2] Toyama Univ, Inst Nat Med, Toyama 9300194, Japan

来源：

FITOTERAPIA | 2008年 / 79卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Asarum plants; cytotoxic activity; traditional medicines;

D O I：

10.1016/j.fitote.2008.02.002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The cytotoxic activity against some tumor cell lines of 16 commonly used species of Asarum was evaluated in this study. All of these plants were widely used in Asian countries as traditional medicines or folk medicines. Their inhibitory activities against four tumor cell lines (HL-60, BGC-823, KB and Bel-7402) were compared. It was observed that 10 of the tested extracts (eight ethanol extracts and two water extracts) among 32 extracts of these plants showed cytotoxic activity. Those 95% ethanol extractions from A. caudigerellum, A. forbesii, A. inflatum and A. maximum exhibited the highest cytotoxic activity, and 95% ethanol extracts or water extracts of A. sieboldii var. seoulense, A. himalaicum, A. splendens and A. crispulatum showed selective activity against one or two cells among the tested tumor cells. This is the first report of Asarum plants possessing cytotoxic activity against tumor cell lines. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：293 / 297

页数：5

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