Class A scavenger receptors and the phagocytosis of apoptotic cells

被引：35
作者：
Platt, N [1 ]
da Silva, RP [1 ]
Gordon, S [1 ]
机构：
[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
来源：
IMMUNOLOGY LETTERS | 1999年 / 65卷 / 1-2期
关键词：
scavenger receptor; macrophage; phagocytosis; apoptosis;
D O I：
10.1016/S0165-2478(98)00118-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Apoptotic cells are rarely seen in situ because of rapid clearance by phagocytes. A number of receptors have been implicated in the recognition and ingestion of dying cells. Class A scavenger receptors (SRs) are multi-domained membrane glycoproteins that can endocytose modified lipoproteins and bind a wide range of ligands. There is growing evidence that they contribute to several biological processes. We present data that suggest class A SRs are involved in the phagocytosis of apoptotic cells. (C) 1999 Elsevier Science B.V. All rights reserved.
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收藏
页码：15 / 19
页数：5
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