Oxidant-Free Selective Synthesis of Functionalized Chroman-4-ones from ortho-Hydroxyacetophenones under HOAc/DMSO Conditions

被引：3
作者：
Wang, Anan [1 ]
Feng, Yuanyuan [1 ]
Li, Shuai [1 ]
Shi, Xu [1 ]
Jiang, Tao-Shan [1 ]
机构：
[1] Anhui Agr Univ, Sch Life Sci, Hefei 230036, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2022年 / 54卷 / 09期
基金：
中国国家自然科学基金;
关键词：
ortho-hydroxyacetophenones; chroman-4-ones; dimethyl sulfoxide; dual synthons; benzopyranopyrimidines; CASCADE RADICAL CYCLIZATION; DIMETHYL-SULFOXIDE; CARBOXYLIC-ACIDS; CONSTRUCTION; DERIVATIVES; CHROMONE; SYNTHON; ACCESS; DMSO; ALDEHYDES;
D O I：
10.1055/s-0040-1719880
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A metal-free and oxidant-free acid-promoted DMSO activation and subsequent reaction is reported. In this protocol, two molecules of DMSO are activated by HOAc and serve as dual synthons which react with ortho-hydroxyacetophenones, affording 3-(methylthiomethyl)chroman-4-ones in moderate to good yields with high selectivity.
引用
收藏
页码：2185 / 2192
页数：8
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