Oxidant-Free Selective Synthesis of Functionalized Chroman-4-ones from ortho-Hydroxyacetophenones under HOAc/DMSO Conditions

被引：3

作者：

Wang, Anan ^{[1
]}

Feng, Yuanyuan ^{[1
]}

Li, Shuai ^{[1
]}

Shi, Xu ^{[1
]}

Jiang, Tao-Shan ^{[1
]}

机构：

[1] Anhui Agr Univ, Sch Life Sci, Hefei 230036, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2022年 / 54卷 / 09期

基金：

中国国家自然科学基金;

关键词：

ortho-hydroxyacetophenones; chroman-4-ones; dimethyl sulfoxide; dual synthons; benzopyranopyrimidines; CASCADE RADICAL CYCLIZATION; DIMETHYL-SULFOXIDE; CARBOXYLIC-ACIDS; CONSTRUCTION; DERIVATIVES; CHROMONE; SYNTHON; ACCESS; DMSO; ALDEHYDES;

D O I：

10.1055/s-0040-1719880

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free and oxidant-free acid-promoted DMSO activation and subsequent reaction is reported. In this protocol, two molecules of DMSO are activated by HOAc and serve as dual synthons which react with ortho-hydroxyacetophenones, affording 3-(methylthiomethyl)chroman-4-ones in moderate to good yields with high selectivity.

引用

页码：2185 / 2192

页数：8

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