Sensitivity Analysis in a Lassa Fever Deterministic Mathematical Model

被引：3

作者：

Abdullahi, Mohammed Baba ^{[1
,2
]}

Doko, Umar Chado ^{[2
]}

Mamuda, Mamman ^{[2
]}

机构：

[1] Univ Sains Malaysia, Sch Math Sci, George Town 11800, Malaysia

[2] Niger State Coll Educ, Dept Math, Sch Sci, Minna, Nigeria

来源：

INTERNATIONAL CONFERENCE ON MATHEMATICS, ENGINEERING AND INDUSTRIAL APPLICATIONS 2014 (ICOMEIA 2014) | 2015年 / 1660卷

关键词：

Sensitivity analysis; Lassa fever; Lassa virus; deterministic; PATHOGENESIS;

D O I：

10.1063/1.4915683

中图分类号：

O29 [应用数学];

学科分类号：

070104 ;

摘要：

Lassa virus that causes the Lassa fever is on the list of potential bio-weapons agents. It was recently imported into Germany, the Netherlands, the United Kingdom and the United States as a consequence of the rapid growth of international traffic. A model with five mutually exclusive compartments related to Lassa fever is presented and the basic reproduction number analyzed. A sensitivity analysis of the deterministic model is performed. This is done in order to determine the relative importance of the model parameters to the disease transmission. The result of the sensitivity analysis shows that the most sensitive parameter is the human immigration, followed by human recovery rate, then person to person contact. This suggests that control strategies should target human immigration, effective drugs for treatment and education to reduced person to person contact.

引用

页数：8

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