Genetic polymorphisms are not associated with energy intake 1 year after Roux-en-Y gastric bypass in women

被引：3

作者：

Sousa Novais, Patricia Fatima ^{[1
]}

Crisp, Alex Harley ^{[2
]}

Leandro-Merhi, Vania Aparecida ^{[3
]}

Galvao Cintra, Renata Maria ^{[1
]}

Rasera Jr, Irineu ^{[4
]}

Marques de Oliveira, Maria Rita ^{[1
]}

机构：

[1] Univ Estadual Paulista, Inst Biosci, Botucatu, SP, Brazil

[2] Univ Metodista Piracicaba, Human Performance Lab, Piracicaba, SP, Brazil

[3] Pontificia Univ Catolica Campinas, Postgrad Program Hlth Sci, Av John Boyd Dunlop,S-N Jardim Ipaussurama, BR-13034685 Campinas, SP, Brazil

[4] Clin Bariatr Piracicaba, Piracicaba, SP, Brazil

来源：

JOURNAL OF HUMAN NUTRITION AND DIETETICS | 2022年 / 35卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

bariatric surgery; food intake; gene polymorphism; obesity; BODY-MASS INDEX; BARIATRIC SURGERY; WEIGHT-LOSS; OBESITY; GENOTYPE; RISK;

D O I：

10.1111/jhn.12984

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background The present study aimed to investigate the influence of food intake on body weight loss (WL) and the association of gene polymorphisms, 1 year after Roux-en-Y gastric bypass (RYGB) surgery. Methods In total, 95 obese women (age ranged 20-50 years) in a Brazilian cohort underwent RYGB surgery and completed the study. Anthropometric measurements and food intake were assessed before and 1 year after surgery. Twelve gene polymorphisms (GHRL rs26802; GHSR rs572169; LEP rs7799039; LEPR rs1137101; 5-HT2C rs3813929; UCP2 rs659366; UCP2 rs660339; UCP3 rs1800849; SH2B1 rs7498665; TAS1R2 rs35874116; TAS1R2 rs9701796; and FTO rs9939609) were determined using a real-time polymerase chain reaction and a TaqMan assay. The subjects were divided into quartiles regarding percentage of excess weight loss (%EWL). The effect of genetic variants on energy and macronutrient intake was evaluated by simple logistic regression, followed by multiple logistic regression. Results Subjects in the first and second quartiles showed a higher initial body mass index. Energy and macronutrient intake before and 1 year after RYGB surgery did not differ between the %EWL quartiles. None of gene polymorphisms investigated showed an association with the estimated energy intake 1 year after surgery. Conclusions In conclusion, the estimate energy and food intake did not predict a greater body WL 1 year after RYGB surgery. In addition, the 12 gene polymorphism investigated did not affect the energy intake among female patients.

引用

页码：739 / 747

页数：9

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