Distribution of delta sleep-inducing peptide in the newborn and infant human hypothalamus: an immunohistochemical study

被引:0
作者
Najimi, M
Bennis, M
Moyse, E
Chigr, F
机构
[1] FST Beni Mellal, Dept Biol & Biotechnol, Unite Genie Biol, Beni Mellal 23000, Morocco
[2] Fac Sci Semlalia, Dept Biol, Unite Neurosci Comportement, Marrakech 40000, Morocco
[3] DOUA, Lab Neurophysiol Sensorielle, F-69100 Villeurbanne, France
关键词
DSIP; immunohistochemistry; development; post-mortem; human brain;
D O I
暂无
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The distribution of delta sleep-inducing peptide immunoreactive cell bodies, fibers, and terminal-like structures was investigated in the normal human hypothalamus during the first postnatal year, using immunohistofluorescence and peroxidase anti-peroxidase techniques. Immunolabeled perikarya were relatively few and were mostly scattered through the anterior (preoptic) and mediobasal regions (infundibular nucleus) of the hypothalamus. DSIP-immunoreactive fibers and terminal-like fibers were observed throughout the entire rostrocaudal extent of the hypothalamus. They exhibit high densities in the preoptic region, the organum vasculosum of lamina terminalis, infundibular nucleus and median eminence. Moderate to low densities of DSIP-immunoreactive fibers were observed in the other hypothalamic structures, located in the anterior and mediobasal regions of hypothalamus, such as periventricular, paraventricular, suprachiasmatic, ventromedial, dorsomedial and parafornical nuclei. in the present study, the analysis of the immunohistochemical pattern of DSIP-immunoreactive neuronal elements in the human infant hypothalamus during the first postnatal year provided evidence of the presence of several differences. We have found qualitative age-related changes in the density of DSIP immunoreactivity in several hypothalamic structures such as the anterior region and the median eminence.
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页码:31 / 42
页数:12
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