Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response

被引：439

作者：

King, Katherine Y. ^{[2
]}

Goodell, Margaret A. ^{[1
]}

机构：

[1] Baylor Coll Med, Stem Cells & Regenerat Med Ctr, Houston, TX 77030 USA

[2] Baylor Coll Med, Infect Dis Sect, Dept Pediat, Houston, TX 77030 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 10期

基金：

美国国家卫生研究院;

关键词：

HEMATOPOIETIC STEM-CELLS; TUMOR-NECROSIS-FACTOR; PROGENITOR CELLS; BONE-MARROW; INTERFERON-GAMMA; GENE-EXPRESSION; INNATE IMMUNITY; SELF-RENEWAL; IFN-GAMMA; DISTINCT;

D O I：

10.1038/nri3062

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cells of the innate and adaptive immune systems are the progeny of a variety of haematopoietic precursors, the most primitive of which is the haematopoietic stem cell. Haematopoietic stem cells have been thought of generally as dormant cells that are only called upon to divide under extreme conditions, such as bone marrow ablation through radiation or chemotherapy. However, recent studies suggest that haematopoietic stem cells respond directly and immediately to infections and inflammatory signals. In this Review, we summarize the current literature regarding the effects of infection on haematopoietic stem cell function and how these effects may have a pivotal role in directing the immune response from the bone marrow.

引用

页码：685 / 692

页数：8

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