The flavanone pinostrobin in the synthesis of coumarin-chalcone hybrids with a triazole linker

被引：13

作者：

Mukusheva, Gulim K. ^{[1
]}

Lipeeva, Alla V. ^{[2
]}

Zhanymkhanova, Pernesh Zh. ^{[1
]}

Shults, Elvira E. ^{[2
,3
]}

Gatilov, Yurii V. ^{[2
,3
]}

Shakirov, Makhmut M. ^{[2
]}

Adekenov, Sergazy M. ^{[1
]}

机构：

[1] Int Res & Prod Holding Phytochem, Karaganda 100009, Kazakhstan

[2] Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia

[3] Novosibirsk State Natl Res Univ, Novosibirsk 630090, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2015年 / 51卷 / 02期

基金：

俄罗斯科学基金会;

关键词：

7-alkynylcoumarins; azide; 2-(bromoalkoxy)chalcones; pinostrobin; 1,2,3-triazoles; DERIVATIVES; CELLS; AGENTS;

D O I：

10.1007/s10593-015-1672-y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of flavanone pinostrobin with dibromoalkanes in acetone in the presence of potassium carbonate followed the path of retro-Michael addition - D-alkylation and resulted in the formation of the respective 2-(bromoalkoxy)chalcones. Treatment of the latter with sodium azide gave the respective azides, which were highly active in the Du-catalyzed 1,3-dipolar cycloaddition reaction. The reaction of these azides with 6-substituted 7-ethynylcoumarins gave coumarin-chalcone hybrids containing a 1,2,3-triazole linker.

引用

页码：146 / 152

页数：7

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