SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

被引：1755
|
作者：
Sungnak, Waradon [1 ]
Huang, Ni [1 ]
Becavin, Christophe [2 ]
Berg, Marijn [3 ,4 ,5 ]
Queen, Rachel [6 ]
Litvinukova, Monika [1 ,7 ]
Talavera-Lopez, Carlos [1 ]
Maatz, Henrike [7 ]
Reichart, Daniel [8 ]
Sampaziotis, Fotios [9 ,10 ,11 ]
Worlock, Kaylee B. [12 ]
Yoshida, Masahiro [12 ]
Barnes, Josephine L. [12 ]
机构：
[1] Wellcome Sanger Inst, Cambridge, England
[2] Univ Cote Azur, CNRS, IPMC, Sophia Antipolis, France
[3] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands
[4] Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma, Groningen, Netherlands
[5] Univ Groningen, Univ Med Ctr Groningen, COPD, Groningen, Netherlands
[6] Newcastle Univ, Fac Med Sci, Biosci Inst, Bioinformat Core Facil, Newcastle Upon Tyne, Tyne & Wear, England
[7] Helmholtz Assoc MDC, Max Delbruck Ctr Mol Med, Cardiovasc & Metab Sci, Berlin, Germany
[8] Harvard Med Sch, Dept Genet, Boston, MA 02115 USA
[9] Univ Cambridge, Wellcome & MRC Cambridge Stem Cell Inst, Cambridge, England
[10] Addenbrookes Hosp, Dept Med, Cambridge, England
[11] Cambridge Univ Hosp, Cambridge Liver Unit, Cambridge, England
[12] UCL, Div Med, UCL Resp, London, England
来源：
NATURE MEDICINE | 2020年 / 26卷 / 05期
基金：
新加坡国家研究基金会; 英国惠康基金; 美国国家卫生研究院; 欧盟地平线“2020”; 英国生物技术与生命科学研究理事会; 中国国家自然科学基金; 英国工程与自然科学研究理事会;
关键词：
FUNCTIONAL RECEPTOR; CORONAVIRUS; PROTEIN; ACE2;
D O I：
10.1038/s41591-020-0868-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
引用
收藏
页码：681 / +
页数：12
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