Microwave-promoted Heck and Suzuki coupling reactions of new 3-(5-bromobenzofuranyl)pyrazole in aqueous media

被引：8
|
作者：
Dawood, Kamal M. [1 ]
Darweesh, Ahmed F. [1 ]
Shaaban, Mohamed R. [1 ]
Farag, Ahmad M. [1 ]
机构：
[1] Cairo Univ, Fac Sci, Dept Chem, Giza 12613, Egypt
来源：
ARKIVOC | 2018年
关键词：
Benzofurans; pyrazoles; palladium catalysis; microwave; C-C cross couplings; ASSISTED SYNTHESIS; ORGANIC-SYNTHESIS; CROSS-COUPLINGS; NONCONVENTIONAL METHODOLOGIES; HETEROARYL BROMIDES; MIZOROKI-HECK; BENZOFURAN; MIYAURA; WATER; ARYL;
D O I：
10.24820/ark.5550190.p010.609
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Suzuki-Miyaura and Mizoroki-Heck cross-coupling reactions of 3-(5-bromobenzofuran-2-yl)-1H-pyrazole with various arylboronic acids and terminal olefins, respectively, were investigated using a benzothiazole-oxime palladium(II) complex, under both thermal and microwave-irradiation conditions, in an open vessel, using aqueous solvent. The benzothiazole-oxime-based Pd(II) complex was found to be an efficient, and highly active pre-catalyst for the cross-coupling reactions, and for the preparation of new C-C cross-coupled compounds of potential biological interest which are difficult to obtain using other synthetic routes. [GRAPHICS] .
引用
收藏
页码：348 / 358
页数：11
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