According to most scientific data. it may be anticipated that radiofrequency radiation is in itself not capable of breaking DNA or being genotoxic, especially when exposure is under so-called athermal conditions. Yet. occasionally significant genetic changes (e.g., increased chromosome aberration frequencies) are found which may be ascribed to small differences in biological sampler and/or in the exposure conditions. Experiments using well defined exposure conditions and materials should therefore be encouraged Furthermore, up to now: little attention was paid to potential synergistic effects with chemical mutagens/carcinogens. Also, the choice of the investigated genetic endpoint is important. This is often not sufficiently taken into consideration when results are evaluated. Finally, experiments on biomonitoring should also consider the presence of possible hypersensitive subjects in the test population.