Impact of Vitamin D Supplementation on Inflammatory Markers' Levels in Obese Patients

被引:4
作者
Wicinski, Michal [1 ]
Ozorowski, Mateusz [1 ]
Wodkiewicz, Eryk [1 ]
Otto, Stephan Walter [2 ]
Kubiak, Karol [3 ]
Malinowski, Bartosz [1 ]
机构
[1] Nicolaus Copernicus Univ, Coll Med Bydgoszcz, Fac Med, Dept Pharmacol & Therapeut, M Curie 9, PL-85090 Bydgoszcz, Poland
[2] Raphaelsklinik, Dept Urol, D-48143 Munster, Germany
[3] St Franziskus Hosp, Dept Obstet & Gynecol, D-48145 Munster, Germany
关键词
vitamin D; inflammation; obesity; pathways; pharmacology; NITRIC-OXIDE SYNTHASE; OXIDATION PROTEIN PRODUCTS; POLYCYSTIC-OVARY-SYNDROME; CENTRAL-NERVOUS-SYSTEM; INSULIN-RESISTANCE; D DEFICIENCY; MITOCHONDRIAL BIOGENESIS; ENDOTHELIAL DYSFUNCTION; VASCULAR INFLAMMATION; LIPID-ACCUMULATION;
D O I
10.3390/cimb43030114
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In view of research suggesting a possible beneficial impact of vitamin D on systemic inflammatory response, the authors decided to investigate an influence of vitamin D supplementation on serum levels of certain inflammatory markers in obese patients. The current study included such biomarkers as interleukin-6 (IL-6), pituitary adenylate cyclase-activating peptide (PACAP), advanced oxidation protein products (AOPP), C-X3-C Motif Chemokine Ligand 1 (CX3CL1), monocyte chemoattractant protein-1 (MCP-1), and nitric oxide (NO). The measurements were performed with the ELISA method before and after 3-month-long supplementation of 2000 IU of vitamin D orally. The results showed that the therapy did not induce any statistically significant changes in serum levels of MCP-1, IL-6, CX3CL1, and PACAP. The supplementation was related to a significant increase in measurements of NO and AOPP levels, although the correlation analysis between vitamin D concentration after its supplementation and the concentration of the molecular parameters did not show significant relation. In conclusion, our study seems to contradict certain aspects of findings available in the literature regarding the vitamin D's impact.
引用
收藏
页码:1606 / 1622
页数:17
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