Unraveling the Relationship of Asthma and COVID-19

被引：6

作者：

Bakakos, Agamemnon ^{[1
]}

Bakakos, Petros ^{[1
]}

Rovina, Nikoletta ^{[1
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Dept Resp Med, Athens 11527, Greece

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2021年 / 11卷 / 12期

关键词：

Asthma; COVID-19; SARS-CoV2; immunology; asthma treatment; RHINOVIRUS; INFLAMMATION; INFECTION; ACE2; OMALIZUMAB; BIOLOGICS; RESPONSES; RECEPTOR; TMPRSS2; AIRWAYS;

D O I：

10.3390/jpm11121374

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Viral infections are one of the main causes of asthma exacerbations. During the COVID-19 era, concerns regarding the relationship of SARS-CoV2 with asthma have been raised. The concerns are both for COVID severity and asthma exacerbations. Many studies on COVID-19 epidemiology and comorbidities have assessed whether asthma represents a risk factor for SARS-CoV2 infection and/or more severe course of the disease. This review covers the current evidence on the prevalence of asthma in COVID-19 and its association with susceptibility to and severity of SARS-CoV2 infection. It will examine the possible role of underlying asthma severity in COVID-19 related outcomes as well as the molecular mechanisms involved in the co-existence of these entities. The possible role of asthma inflammatory phenotypes will also be evaluated. Finally, the impact of asthma comorbidities and the implications of asthma medication on COVID-19 will be addressed.

引用

页数：11

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