Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle

被引：108

作者：

Kolb, Jan Philip ^{[1
,2
]}

Klein, Thomas ^{[2
,3
]}

Kufner, Corinna L. ^{[2
]}

Wieser, Wolfgang ^{[2
,3
]}

Neubauer, Aljoscha S. ^{[4
]}

Huber, Robert ^{[1
,2
]}

机构：

[1] Univ Lubeck, Inst Biomed Opt, D-23562 Lubeck, Germany

[2] Univ Munich, Fak Phys, Lehrstuhl BioMol Opt, D-80538 Munich, Germany

[3] Optores GmbH, D-80335 Munich, Germany

[4] Univ Munich, Augenklin, D-80336 Munich, Germany

来源：

BIOMEDICAL OPTICS EXPRESS | 2015年 / 6卷 / 05期

关键词：

OPTICAL COHERENCE TOMOGRAPHY; SCANNING LASER OPHTHALMOSCOPY; DOMAIN MODE-LOCKING; SWEPT SOURCE; HUMAN EYE; DIABETIC-RETINOPATHY; ANTERIOR SEGMENT; HIGH-RESOLUTION; MEGAHERTZ OCT; PUPIL SIZE;

D O I：

10.1364/BOE.6.001534

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We evaluate strategies to maximize the field of view (FOV) of in vivo retinal OCT imaging of human eyes. Three imaging modes are tested: Single volume imaging with 85 degrees FOV as well as with 100 degrees and stitching of five 60 degrees images to a 100 degrees mosaic (measured from the nodal point). We employ a MHz-OCT system based on a 1060nm Fourier domain mode locked (FDML) laser with a depth scan rate of 1.68MHz. The high speed is essential for dense isotropic sampling of the large areas. Challenges caused by the wide FOV are discussed and solutions to most issues are presented. Detailed information on the design and characterization of our sample arm optics is given. We investigate the origin of an angle dependent signal falloff which we observe towards larger imaging angles. It is present in our 85 degrees and 100 degrees single volume images, but not in the mosaic. Our results suggest that 100 degrees FOV OCT is possible with current swept source OCT technology. (C) 2015 Optical Society of America

引用

页码：1534 / 1552

页数：19

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