Solid and hollow metallic glass microneedles for transdermal drug-delivery

被引:57
作者
Hu, Zhonglue [1 ,2 ]
Meduri, Chandra S. [2 ]
Ingrole, Rohan S. J. [3 ]
Gill, Harvinder S. [3 ]
Kumar, Golden [2 ]
机构
[1] Zhejiang Normal Univ, Coll Engn, Jinhua 321004, Zhejiang, Peoples R China
[2] Univ Texas Dallas, Dept Mech Engn, Richardson, TX 75080 USA
[3] Texas Tech Univ, Dept Chem Engn, Lubbock, TX 79409 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
COATED MICRONEEDLES; DRAWING LITHOGRAPHY; FABRICATION; VACCINATION; PATCHES;
D O I
10.1063/5.0008983
中图分类号
O59 [应用物理学];
学科分类号
摘要
Metallic microneedles are attractive for painless transdermal drug-delivery. However, fabrication techniques for metal microneedles are often complex and multi-step. In this study, a scalable manufacturing of metallic microneedle arrays is presented using thermoplastic drawing of metallic glasses. Microneedles with tunable lengths and tips are produced by controlling the rheology and fracture of metallic glass. The same drawing process can generate solid and hollow microneedles simply by varying the thickness of metallic glass. The mechanism of thickness dependent transition from solid to hollow profiles is described by the viscous buckling of metallic liquid. In vitro skin insertion tests demonstrate that both solid and hollow metallic glass microneedles can pierce porcine skin and deliver model drugs.
引用
收藏
页数:5
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