The application of proteomics in the diagnosis and treatment of bronchial asthma

被引：19
作者：
Xu, Peng [1 ]
Wang, Lingwei [1 ]
Chen, Dandan [1 ]
Feng, Mengjie [1 ]
Lu, Yongzhen [1 ]
Chen, Rongchang [1 ]
Qiu, Chen [1 ]
Li, Jie [1 ]
机构：
[1] Jinan Univ, Clin Med Coll 2,Affiliated Hosp 1, Southern Univ Sci & Technol,Shenzhen Peoples Hosp, Key Lab Shenzhen Resp Dis,Shenzhen Inst Resp Dis, Shenzhen 518006, Peoples R China
来源：
ANNALS OF TRANSLATIONAL MEDICINE | 2020年 / 8卷 / 04期
关键词：
Proteomics; bronchial asthma; bioinformatics; mass spectrometry (MS); MASS-SPECTROMETRY; LAVAGE FLUID; COPD;
D O I：
10.21037/atm.2020.02.30
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Bronchial asthma is a common chronic inflammatory disease of the airways. Although its pathogenic mechanism remains unknown, it is influenced by both genetic and environmental factors. The emergence and application of proteomic technologies can help to facilitate analysis of the changes in transcription factors, inflammatory mediators, chemokines, cytokines, and cell apoptosis-and proliferation-related proteins in the pathological processes of asthma. Proteomic technologies can unearth prospects and theoretical bases for improved understanding of the biological mechanism of asthma and effective identification of diagnostic and therapeutic targets.
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页数：7
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