Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues

被引：49
作者：
Ferraz da Costa, Danielly C. [1 ]
Rangel, Luciana Pereira [2 ]
Duarte da Cunha Martins-Dinis, Mafalda Maria [3 ]
da Silva Ferretti, Giulia Diniz [3 ]
Ferreira, Vitor F. [4 ]
Silva, Jerson L. [3 ]
机构：
[1] Univ Estado Rio de Janeiro, Inst Nutr, Dept Nutr Basica & Expt, BR-20550013 Rio De Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, Fac Farm, BR-21941902 Rio De Janeiro, Brazil
[3] Univ Fed Rio de Janeiro, Programa Biol Estrutural, Inst Bioquim Med Leopoldo Meis, Inst Nacl Ciencia & Tecnol Biol Estrutural & Bioi, BR-21941902 Rio De Janeiro, Brazil
[4] Univ Fed Fluminense, Fac Farm, Dept Tecnol Farmaceut, BR-24241000 Rio De Janeiro, Brazil
来源：
MOLECULES | 2020年 / 25卷 / 04期
关键词：
resveratrol; beta-lapachone; cancer; CELL-CYCLE ARREST; BREAST-CANCER CELLS; SIGNAL-TRANSDUCTION PATHWAYS; PRION-LIKE AGGREGATION; INHIBITS TUMOR-GROWTH; OXIDOREDUCTASE; NQO1; PROSTATE-CANCER; HUMAN LUNG; NAD(P)H-QUINONE OXIDOREDUCTASE; OXIDATIVE STRESS;
D O I：
10.3390/molecules25040893
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review aims to explore the potential of resveratrol, a polyphenol stilbene, and beta-lapachone, a naphthoquinone, as well as their derivatives, in the development of new drug candidates for cancer. A brief history of these compounds is reviewed along with their potential effects and mechanisms of action and the most recent attempts to improve their bioavailability and potency against different types of cancer.
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页数：22
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