EMT A new vision of hypoxia promoting cancer progression

被引：213

作者：

Jiang, Jian ^{[1
]}

Tang, Ya-ling ^{[1
]}

Liang, Xin-hua ^{[1
,2
]}

机构：

[1] Sichuan Univ, W China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610064, Peoples R China

[2] Sichuan Univ, W China Hosp Stomatol, Dept Oral & Maxillofacial Surg, Chengdu 610064, Peoples R China

来源：

CANCER BIOLOGY & THERAPY | 2011年 / 11卷 / 08期

基金：

中国国家自然科学基金;

关键词：

epithelial to mesenchymal transition (EMT); EMT regulators; hypoxia; hypoxia inducible factor (HIF); inflammatory cytokines; metastasis; EPITHELIAL-MESENCHYMAL TRANSITION; ENDOTHELIAL GROWTH-FACTOR; INDUCIBLE FACTOR-I; NF-KAPPA-B; E-CADHERIN EXPRESSION; TUMOR-SUPPRESSOR PROTEIN; NECROSIS-FACTOR-ALPHA; TGF-BETA; CELL-MIGRATION; SNAIL EXPRESSION;

D O I：

10.4161/cbt.11.8.15274

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A hypoxic microenvironment plays a critical role in the development and progression of tumors. The epithelial to mesenchymal transition (EMT) is a process by which epithelial cells lose their polarity and are converted to a mesenchymal phenotype, which is regarded as a critical event in morphogenetic changes during embryonic development, wound healing and cancer metastasis. Recent advances in our understanding of the molecular pathways that govern the association of hypoxia with malignant tumors point to the epithelial to mesenchymal transition (EMT). The hypoxic microenvironment common to cancer cells emerges as an important factor in the induction of a pathological EMT, which is a key link in cancer progression. This review presents the potential molecular mechanisms underlying the hypoxia/HIF-dependent regulation of the EMT in cancer.

引用

页码：714 / 723

页数：10

共 177 条

[1] Genetic evidence for a tumor suppressor role of HIF-2α [J].

Acker, T ;

Diez-Juan, A ;

Aragones, J ;

Tjwa, M ;

Brusselmans, K ;

Moons, L ;

Fukumura, D ;

Moreno-Murciano, MP ;

Herbert, JM ;

Burger, A ;

Riedel, J ;

Elverl, G ;

Flamme, I ;

Maxwell, PH ;

Collen, D ;

Dewerchin, M ;

Jain, RK ;

Plate, KH ;

Carmeliet, P .

CANCER CELL, 2005, 8 (02) :131-141

[2] Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease [J].

Acloque, Herve ;

Adams, Meghan S. ;

Fishwick, Katherine ;

Bronner-Fraser, Marianne ;

Angela Nieto, M. .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (06) :1438-1449

[3] Role of hypoxia-inducible factor-1α in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes [J].

Ahn, J. K. ;

Koh, E. -M. ;

Cha, H. -S. ;

Lee, Y. S. ;

Kim, J. ;

Bae, E. -K. ;

Ahn, K. -S. .

RHEUMATOLOGY, 2008, 47 (06) :834-839

[4] Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence [J].

Ansieau, Stephane ;

Bastid, Jeremy ;

Doreau, Agnes ;

Morel, Anne-Pierre ;

Bouchet, Benjamin P. ;

Thomas, Clemence ;

Fauvet, Frederique ;

Puisieux, Isabelle ;

Doglioni, Claudio ;

Piccinin, Sara ;

Maestro, Roberta ;

Voeltzel, Thibault ;

Selmi, Abdelkader ;

Valsesia-Wittmann, Sandrine ;

de Fromentel, Claude Caron ;

Puisieux, Alain .

CANCER CELL, 2008, 14 (01) :79-89

[5] Hypoxia-induced dedifferentiation of tumor cells -: A mechanism behind heterogeneity and aggressiveness of solid tumors [J].

Axelson, H ;

Fredlund, E ;

Ovenberger, M ;

Landberg, G ;

Påhlman, S .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2005, 16 (4-5) :554-563

[6] VHL and HIF signalling in renal cell carcinogenesis [J].

Baldewijns, Marcella M. ;

van Vlodrop, Iris J. H. ;

Vermeulen, Peter B. ;

Soetekouw, Patricia M. M. B. ;

van Engeland, Manon ;

de Bruine, Adriaan P. .

JOURNAL OF PATHOLOGY, 2010, 221 (02) :125-138

[7] Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004-2010) [J].

Ban, Hyun Seung ;

Uto, Yoshikazu ;

Nakamura, Hiroyuki .

EXPERT OPINION ON THERAPEUTIC PATENTS, 2011, 21 (02) :131-146

[8] Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer [J].

Banks, RE ;

Tirukonda, P ;

Taylor, C ;

Hornigold, N ;

Astuti, D ;

Cohen, D ;

Maher, ER ;

Stanley, AJ ;

Harnden, P ;

Joyce, A ;

Knowles, M ;

Selby, PJ .

CANCER RESEARCH, 2006, 66 (04) :2000-2011

[9] Effects of HIF-1 alpha and HIF2 alpha on Growth andMetabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts [J].

Biswas, Swethajit ;

Troy, Helen ;

Leek, Russell ;

Chung, Yuen-Li ;

Li, Ji-liang ;

Raval, Raju R. ;

Turley, Helen ;

Gatter, Kevin ;

Pezzella, Francesco ;

Griffiths, John R. ;

Stubbs, Marion ;

Harris, Adrian L. .

JOURNAL OF ONCOLOGY, 2010, 2010

[10] Correlation of Snail expression with histological grade and lymph node status in breast carcinomas [J].

Blanco, MJ ;

Moreno-Bueno, G ;

Sarrio, D ;

Locascio, A ;

Cano, A ;

Palacios, J ;

Nieto, MA .

ONCOGENE, 2002, 21 (20) :3241-3246

← 1 2 3 4 5 6 7 8 9 10 →