Intracellular targeting delivery of liposomal drugs to solid tumors based on EPR effects

被引:493
作者
Maruyama, Kazuo [1 ]
机构
[1] Teikyo Univ, Fac Pharmaceut Sci, Midori Ku, Sagamihara, Kanagawa 2525195, Japan
关键词
Liposome; PEG-liposome; Transferrin; Boron neutron-capture therapy (BNCT); Oxaliplatin; Passive targeting; Intracellular targeting; Fab' fragment; NEUTRON-CAPTURE THERAPY; PROLONGED CIRCULATION TIME; ANTITUMOR-ACTIVITY; MACROMOLECULAR THERAPEUTICS; COATED LIPOSOMES; FAB FRAGMENT; DOXORUBICIN; PHARMACOKINETICS; TRANSFERRIN; CANCER;
D O I
10.1016/j.addr.2010.09.003
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The success of an effective drug delivery system using liposomes for solid tumor targeting based on EPR effects is highly dependent on both size ranging from 100-200 nm in diameter and prolonged circulation half-life in the blood. A major development was the synthesis of PEG-liposomes with a prolonged circulation time in the blood. Active targeting of immunoliposomes to the solid tumor tissue can be achieved by the Fab' fragment which is better than whole IgG in terms of designing PEG-immunoliposomes with prolonged circulation. For intracellular targeting delivery to solid tumors based on EPR effects, transferrin-PEG-liposomes can stay in blood circulation for a long time and extravasate into the extravascular of tumor tissue by the EPR effect as PEG-liposomes. The extravasated transferrin-PEG-liposomes can maintain anti cancer drugs in interstitial space for a longer period, and deliver them into the cytoplasm of tumor cells via transferrin receptor-mediated endocytosis. Transferrin-PEG-liposomes improve the safety and efficacy of anti cancer drug by both passive targeting by prolonged circulation and active targeting by transferrin. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码:161 / 169
页数:9
相关论文
共 59 条
[31]   CHARACTERIZATION OF INVIVO IMMUNOLIPOSOME TARGETING TO PULMONARY ENDOTHELIUM [J].
MARUYAMA, K ;
HOLMBERG, E ;
KENNEL, SJ ;
KLIBANOV, A ;
TORCHILIN, VP ;
HUANG, L .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1990, 79 (11) :978-984
[32]   Intracellular targeting of sodium mercaptoundecahydrododecaborate (BSH) to solid tumors by transferrin-PEG liposomes, for boron neutron-capture therapy (BNCT) [J].
Maruyama, K ;
Ishida, O ;
Kasaoka, S ;
Takizawa, T ;
Utoguchi, N ;
Shinohara, A ;
Chiba, M ;
Kobayashi, H ;
Eriguchi, M ;
Yanagie, H .
JOURNAL OF CONTROLLED RELEASE, 2004, 98 (02) :195-207
[33]   Immunoliposomes bearing polyethyleneglycol-coupled Fab' fragment show prolonged circulation time and high extravasation into targeted solid tumors in vivo [J].
Maruyama, K ;
Takahashi, N ;
Tagawa, T ;
Nagaike, K ;
Iwatsuru, M .
FEBS LETTERS, 1997, 413 (01) :177-180
[34]   PHOSPHATIDYL POLYGLYCEROLS PROLONG LIPOSOME CIRCULATION IN-VIVO [J].
MARUYAMA, K ;
OKUIZUMI, S ;
ISHIDA, O ;
YAMAUCHI, H ;
KIKUCHI, H ;
IWATSURU, M .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1994, 111 (01) :103-107
[35]   Possibility of active targeting to tumor tissues with liposomes [J].
Maruyama, K ;
Ishida, O ;
Takizawa, T ;
Moribe, K .
ADVANCED DRUG DELIVERY REVIEWS, 1999, 40 (1-2) :89-102
[36]   TARGETABILITY OF NOVEL IMMUNOLIPOSOMES MODIFIED WITH AMPHIPATHIC POLY(ETHYLENE GLYCOL)S CONJUGATED AT THEIR DISTAL TERMINALS TO MONOCLONAL-ANTIBODIES [J].
MARUYAMA, K ;
TAKIZAWA, T ;
YUDA, T ;
KENNEL, SJ ;
HUANG, L ;
IWATSURU, M .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1995, 1234 (01) :74-80
[37]   PROLONGED CIRCULATION TIME INVIVO OF LARGE UNILAMELLAR LIPOSOMES COMPOSED OF DISTEAROYL PHOSPHATIDYLCHOLINE AND CHOLESTEROL CONTAINING AMPHIPATHIC POLY(ETHYLENE GLYCOL) [J].
MARUYAMA, K ;
YUDA, T ;
OKAMOTO, A ;
KOJIMA, S ;
SUGINAKA, A ;
IWATSURU, M .
BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1128 (01) :44-49
[38]  
MATSUMURA Y, 1986, CANCER RES, V46, P6387
[39]   TRANSFERRIN RECEPTOR IN ORAL TUMORS [J].
MIYAMOTO, T ;
TANAKA, N ;
EISHI, Y ;
AMAGASA, T .
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 1994, 23 (06) :430-433
[40]  
MOGHIMI SM, 1992, BIOCHIM BIOPHYS ACTA, V1135, P269