Organization of TNIK in dendritic spines

被引：18

作者：

Burette, Alain C. ^{[1
]}

Phend, Kristen D. ^{[1
]}

Burette, Susan ^{[1
]}

Lin, Qingcong ^{[3
]}

Liang, Musen ^{[4
]}

Foltz, Gretchen ^{[5
]}

Taylor, Noel ^{[6
]}

Wang, Qi ^{[7
]}

Brandon, Nicholas J. ^{[8
]}

Bates, Brian ^{[9
]}

Ehlers, Michael D. ^{[7
]}

Weinberg, Richard J. ^{[1
,2
]}

机构：

[1] Univ N Carolina, Dept Cell Biol & Physiol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Neurosci Ctr, Chapel Hill, NC 27599 USA

[3] Shenogen Pharma Grp, Beijing 102206, Peoples R China

[4] Dept Pharmacokinet Dynam & Metab, Andover, MA 01810 USA

[5] Pfizer, Clin Res Unit, New Haven, CT 06511 USA

[6] Eisai Product Creat Syst, Biomarker & Personalized Med Grp, Andover, MA 01810 USA

[7] Pfizer, Neurosci Res Unit, Cambridge, MA 02139 USA

[8] AstraZeneca Neurosci IMED, Cambridge, MA 02139 USA

[9] Ctr Therapeut Innovat, Boston, MA 02115 USA

来源：

JOURNAL OF COMPARATIVE NEUROLOGY | 2015年 / 523卷 / 13期

基金：

美国国家卫生研究院;

关键词：

TNIK; dendritic spine; PSD; cerebral cortex; striatum RRID:AB_11212843; RRID:AB_1858225; RRID:AB_11213019; RRID:nif-0000-30467; RRID:AB_94396; NCK-INTERACTING KINASE; POSTSYNAPTIC DENSITY PROTEINS; WNT TARGET GENES; AMPA RECEPTOR; CHOLINE-ACETYLTRANSFERASE; NMDA RECEPTOR; GLUTAMATERGIC SYNAPSES; N-CADHERIN; RAT; SCHIZOPHRENIA;

D O I：

10.1002/cne.23770

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Tumor necrosis factor receptor-associated factor 2 (TRAF2)- and noncatalytic region of tyrosine kinase (NCK)-interacting kinase (TNIK) has been identified as an interactor in the psychiatric risk factor, Disrupted in Schizophrenia 1 (DISC1). As a step toward deciphering its function in the brain, we performed high-resolution light and electron microscopic immunocytochemistry. We demonstrate here that TNIK is expressed in neurons throughout the adult mouse brain. In striatum and cerebral cortex, TNIK concentrates in dendritic spines, especially in the vicinity of the lateral edge of the synapse. Thus, TNIK is highly enriched at a microdomain critical for glutamatergic signaling. J. Comp. Neurol. 523:1913-1924, 2015 (C) 2015 Wiley Periodicals, Inc.

引用

页码：1913 / 1924

页数：12

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