Diagnostic potential of peritoneal fluid biomarkers of endometriosis

被引：26

作者：

Rizner, Tea Lanisnik ^{[1
]}

机构：

[1] Univ Ljubljana, Fac Med, Inst Biochem, Vrazov Trg 2, Ljubljana 1000, Slovenia

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2015年 / 15卷 / 04期

关键词：

diagnosis; endometriosis; omics; prognosis; review; ENDOTHELIAL GROWTH-FACTOR; OXIDATIVE STRESS MARKERS; QUALITY-OF-LIFE; OVARIAN ENDOMETRIOSIS; INFILTRATING ENDOMETRIOSIS; LEPTIN CONCENTRATIONS; PLACENTAL PROTEIN-14; MILD ENDOMETRIOSIS; MENSTRUAL-CYCLE; PELVIC PAIN;

D O I：

10.1586/14737159.2015.1015994

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Endometriosis is defined as the presence of endometrial glands and stroma outside the uterus, in different parts of the peritoneal cavity. It affects up to 10% of reproductive-age women and up to 50% of women with infertility. Surgical diagnosis of endometriosis is still the gold standard, with no diagnostic biomarkers available. Medical therapies target the symptoms and not the disease itself, and surgical treatment cannot prevent recurrence. As peritoneal fluid reflects the altered peritoneal microenvironment of endometriosis patients, it can provide a wealth of information on pathophysiological processes and potential biomarkers. This report reviews the molecular biomarkers identified in peritoneal fluid over the last 5 years and discusses their potential applications for diagnosis, prognosis and drug therapy.

引用

页码：557 / 580

页数：24

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