Copper(II) catalyzed domino synthesis of quinoline derivatives from arylamines and alkynes

被引：23

作者：

Dai, Huimin ^{[1
]}

Li, Chun-Xiao ^{[1
]}

Yu, Chao ^{[1
]}

Wang, Zihao ^{[1
]}

Yan, Hong ^{[1
]}

Lu, Changsheng ^{[1
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210023, Jiangsu, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2017年 / 4卷 / 10期

关键词：

SUBSTITUTED QUINOLINES; INTERMOLECULAR HYDROAMINATION; REGIOSELECTIVE SYNTHESIS; BOND ACTIVATION; AMINATION; CYCLIZATION; ANILINES; INDOLES; SCOPE; FUNCTIONALIZATION;

D O I：

10.1039/c7qo00333a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Cu(OAc)(2)center dot H2O catalyzed domino reaction of primary arylamines and electron-deficient terminal alkynes was developed at room temperature. It provides a convenient access to a variety of 2,4-disubstituted quinolines in good to excellent yields without protection from moisture or air. Control experiments suggest that the reaction might be initiated from alkyne homocoupling, followed by copper catalyzed hydroamination and cyclization.

引用

页码：2008 / 2011

页数：4

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