Alpha-Synuclein and Cognitive Decline in Parkinson Disease

被引：23

作者：

Fan, Tian-Sin ^{[1
]}

Liu, Sam Chi-Hao ^{[2
]}

Wu, Ruey-Meei ^{[2
]}

机构：

[1] Natl Taiwan Univ Hosp, Hsin Chu Branch, Dept Neurol, Hsinchu 300, Taiwan

[2] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Neurol, Coll Med, Taipei 100, Taiwan

来源：

LIFE-BASEL | 2021年 / 11卷 / 11期

关键词：

Parkinson disease; alpha-synuclein; cognition; dementia; non-motor symptom; Lewy body; genetic; SNCA; neurodegeneration; biomarker; LEWY BODY PATHOLOGY; CLINICAL DIAGNOSTIC-CRITERIA; CEREBROSPINAL-FLUID; ALZHEIMERS-DISEASE; GAUCHER-DISEASE; MOUSE MODEL; GLUCOCEREBROSIDASE MUTATIONS; MITOCHONDRIAL DYSFUNCTION; PROTEASOME DYSFUNCTION; PREFORMED FIBRILS;

D O I：

10.3390/life11111239

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Parkinson disease (PD) is the second most common neurodegenerative disorder in elderly people. It is characterized by the aggregation of misfolded alpha-synuclein throughout the nervous system. Aside from cardinal motor symptoms, cognitive impairment is one of the most disabling non-motor symptoms that occurs during the progression of the disease. The accumulation and spreading of alpha-synuclein pathology from the brainstem to limbic and neocortical structures is correlated with emerging cognitive decline in PD. This review summarizes the genetic and pathophysiologic relationship between alpha-synuclein and cognitive impairment in PD, together with potential areas of biomarker advancement.

引用

页数：23

共 249 条

[1] Neuropathology of dementia in Parkinson's disease: A prospective, community-based study [J].

Aarsland, D ;

Perry, R ;

Brown, A ;

Larsen, JP ;

Ballard, C .

ANNALS OF NEUROLOGY, 2005, 58 (05) :773-776

[2] Risk of dementia in Parkinson's disease - A community-based, prospective study [J].

Aarsland, D ;

Andersen, K ;

Larsen, JP ;

Lolk, A ;

Nielsen, H ;

Kragh-Sorensen, P .

NEUROLOGY, 2001, 56 (06) :730-736

[3] The epidemiology of dementia associated with Parkinson disease [J].

Aarsland, Dag ;

Kurz, Martin Wilhelm .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2010, 289 (1-2) :18-22

[4] α-synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities [J].

Alam, Parvez ;

Bousset, Luc ;

Melki, Ronald ;

Otzen, Daniel E. .

JOURNAL OF NEUROCHEMISTRY, 2019, 150 (05) :522-534

[5] Cognitive and Motor Function in Long-Duration PARKIN-Associated Parkinson Disease [J].

Alcalay, Roy N. ;

Caccappolo, Elise ;

Mejia-Santana, Helen ;

Tang, Ming Xin ;

Rosado, Llency ;

Reilly, Martha Orbe ;

Ruiz, Diana ;

Louis, Elan D. ;

Comella, Cynthia L. ;

Nance, Martha A. ;

Bressman, Susan B. ;

Scott, William K. ;

Tanner, Caroline M. ;

Mickel, Susan F. ;

Waters, Cheryl H. ;

Fahn, Stanley ;

Cote, Lucien J. ;

Frucht, Steven J. ;

Ford, Blair ;

Rezak, Michael ;

Novak, Kevin E. ;

Friedman, Joseph H. ;

Pfeiffer, Ronald F. ;

Marsh, Laura ;

Hiner, Bradley ;

Payami, Haydeh ;

Molho, Eric ;

Factor, Stewart A. ;

Nutt, John G. ;

Serrano, Carmen ;

Arroyo, Maritza ;

Ottman, Ruth ;

Pauciulo, Michael W. ;

Nichols, William C. ;

Clark, Lorraine N. ;

Marder, Karen S. .

JAMA NEUROLOGY, 2014, 71 (01) :62-67

[6] Autonomic dysfunction in dementia [J].

Allan, L. M. ;

Ballard, C. G. ;

Allen, J. ;

Murray, A. ;

Davidson, A. W. ;

McKeith, I. G. ;

Kenny, R. A. .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2007, 78 (07) :671-677

[7] Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Schapira, Anthony H. ;

Gardiner, Chris ;

Sargent, Ian L. ;

Wood, Matthew J. A. ;

Cooper, J. Mark .

NEUROBIOLOGY OF DISEASE, 2011, 42 (03) :360-367

[8] Lipids at the Crossroad of α-Synuclein Function and Dysfunction: Biological and Pathological Implications [J].

Alza, Natalia P. ;

Iglesias Gonzalez, Pablo A. ;

Conde, Melisa A. ;

Uranga, Romina M. ;

Salvador, Gabriela A. .

FRONTIERS IN CELLULAR NEUROSCIENCE, 2019, 13

[9] Phosphorylation of Ser-129 is the dominant pathological modification of α-synuclein in familial and sporadic Lewy body disease [J].

Anderson, John P. ;

Walker, Donald E. ;

Goldstein, Jason M. ;

de laat, Rian ;

Banducci, Kelly ;

Caccavello, Russell J. ;

Barbour, Robin ;

Huang, Jiping ;

Kling, Kristin ;

Lee, Michael ;

Diep, Linnea ;

Keim, Pamela S. ;

Shen, Xiaofeng ;

Chataway, Tim ;

Schlossmacher, Michael G. ;

Seubert, Peter ;

Schenk, Dale ;

Sinha, Sukanto ;

Gai, Wei Ping ;

Chilcote, Tamie J. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (40) :29739-29752

[10] Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease [J].

Auluck, PK ;

Chan, HYE ;

Trojanowski, JQ ;

Lee, VMY ;

Bonini, NM .

SCIENCE, 2002, 295 (5556) :865-868

← 1 2 3 4 5 6 7 8 9 10 →