Fluorescent humanized anti-CEA antibody specifically labels metastatic pancreatic cancer in a patient-derived orthotopic xenograft (PDOX) mouse model

被引：0

作者：

Lwin, Thinzar M. ^{[1
]}

Miyake, Kentaro ^{[1
,2
,3
]}

Murakami, Takashi ^{[1
,2
,3
]}

DeLong, Jonathan C. ^{[1
]}

Yazaki, Paul J. ^{[4
]}

Shivley, John E. ^{[4
]}

Clary, Bryan ^{[1
]}

Hoffman, Robert M. ^{[1
,2
]}

Bouvet, Michael ^{[1
,5
]}

机构：

[1] Univ Calif San Diego, Dept Surg, San Diego, CA 92103 USA

[2] AntiCanc Inc, San Diego, CA USA

[3] Yokohama City Univ, Grad Sch Med, Dept Gastroenterol Surg, Yokohama, Kanagawa, Japan

[4] City Hope Natl Med Ctr, 1500 E Duarte Rd, Duarte, CA 91010 USA

[5] VA San Diego Healthcare Syst, San Diego, CA USA

来源：

MOLECULAR-GUIDED SURGERY: MOLECULES, DEVICES, AND APPLICATIONS IV | 2018年 / 10478卷

关键词：

Fluorescence-guided-surgery; LICOR IRDye800CW; Anti-CEA antibody; Patient derived orthotopic xenograft Model; Pancreatic cancer; In-Situ tumor visualization; Fluorescence imaging; Tumor specific fluorescence; GUIDED SURGERY; MARGIN STATUS; RESECTION; PANCREATICODUODENECTOMY; IMPACT;

D O I：

10.1117/12.2292546

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Specific tumor targeting can result in selective labeling of cancer in vivo for surgical navigation. In the present study, we show that the use of an anti-CEA antibody conjugated to the near-infrared (NIR) fluorescent dye, IRDye800CW, can selectively target and label pancreatic cancer and its metastases in a clinically relevant patient derived xenograft mouse model.

引用

页数：10

共 50 条

[41] High-fat diet promotes tumor growth in the patient-derived orthotopic xenograft (PDOX) mouse model of ER positive endometrial cancer
Shen, Ke
Shen, Dandan
Jin, Dongdong
Zheng, Yichao
Zhu, Yuanhang
Zhao, Xinyue
Zhang, Zhenan
Wang, Nannan
Chen, Huanhuan
Yang, Li
SCIENTIFIC REPORTS, 2023, 13 (01)
[42] Effect of Salmonella typhimurium A1-R on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) in nude mice.
Zhao, Ming
Hiroshima, Yukihiko
Maawy, Ali
Zhang, Yong
Uehara, Fuminari
Miwa, Shinji
Yano, Shuya
Bouvet, Michael
Endo, Itaru
Hoffman, Robert M.
JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
[43] MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX)
Kawaguchi, Kei
Igarashi, Kentaro
Murakami, Takashi
Kiyuna, Tasuku
Lwin, Thinzar M.
Hwang, Ho Kyoung
Delong, Jonathan C.
Clary, Bryan M.
Bouvet, Michael
Unno, Michiaki
Hoffman, Robert M.
ONCOTARGET, 2017, 8 (29) : 47490 - 47496
[44] A portable imaging system for fluorescence-guided surgery on a human colon cancer patient-derived orthotopic xenograft (PDOX™) nude mouse model
Hiroshima, Yukihiko
Maawy, Ali
Kaushal, Sharmeela
Zhang, Yong
Uehara, Fuminari
Miwa, Shinji
Yano, Shuya
Sato, Sho
Murakami, Takashi
Momiyama, Masashi
Chishima, Takashi
Tanaka, Kuniya
Bouvet, Michael
Endo, Itaru
Hoffman, Robert M.
MOLECULAR CANCER RESEARCH, 2014, 12
[45] Regorafenib regressed a doxorubicin-resistant Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude mouse model
Miyake, Kentaro
Kiyuna, Tasuku
Kawaguchi, Kei
Higuchi, Takashi
Oshiro, Hiromichi
Zhang, Zhiying
Wangsiricharoen, Sintawat
Razmjooei, Sahar
Li, Yunfeng
Nelson, Scott D.
Murakami, Takashi
Hiroshima, Yukihiko
Matsuyama, Ryusei
Bouvet, Michael
Chawla, Sant P.
Singh, Shree Ram
Endo, Itaru
Hoffman, Robert M.
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2019, 83 (05) : 809 - 815
[46] Cervical Cancer Patient-Derived Orthotopic Xenograft (PDOX) Is Sensitive to Cisplatinum and Resistant to Nab-paclitaxel
Murakami, Takashi
Murata, Takuya
Kawaguchi, Kei
Kiyuna, Tasuku
Igarashi, Kentaro
Hwang, Ho Kyoung
Hiroshima, Yukihiko
Hozumi, Chihiro
Komatsu, Shin
Kikuchi, Takashi
Lwin, Thinzar M.
Delong, Jonathan C.
Miyake, Kentaro
Zhang, Yong
Tanaka, Kuniya
Bouvet, Michael
Endo, Itaru
Hoffman, Robert M.
ANTICANCER RESEARCH, 2017, 37 (01) : 61 - 65
[47] Regorafenib regressed a doxorubicin-resistant Ewing’s sarcoma in a patient-derived orthotopic xenograft (PDOX) nude mouse model
Kentaro Miyake
Tasuku Kiyuna
Kei Kawaguchi
Takashi Higuchi
Hiromichi Oshiro
Zhiying Zhang
Sintawat Wangsiricharoen
Sahar Razmjooei
Yunfeng Li
Scott D. Nelson
Takashi Murakami
Yukihiko Hiroshima
Ryusei Matsuyama
Michael Bouvet
Sant P. Chawla
Shree Ram Singh
Itaru Endo
Robert M. Hoffman
Cancer Chemotherapy and Pharmacology, 2019, 83 : 809 - 815
[48] Patient-derived orthotopic xenograft (PDOX) mouse model of adult rhabdomyosarcoma invades and recurs after resection in contrast to the subcutaneous ectopic model
Igarashi, Kentaro
Kawaguchi, Kei
Kiyuna, Tasuku
Murakami, Takashi
Miwa, Shinji
Nelson, Scott D.
Dry, Sarah M.
Li, Yunfeng
Singh, Arun
Kimura, Hiroaki
Hayashi, Katsuhiro
Yamamoto, Norio
Tsuchiya, Hiroyuki
Eilber, Fritz C.
Hoffman, Robert M.
CELL CYCLE, 2017, 16 (01) : 91 - 94
[49] Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model
Murakami, Takashi
Li, Shukuan
Han, Qinghong
Tan, Yuying
Kiyuna, Tasuku
Igarashi, Kentaro
Kawaguchi, Kei
Hwang, Ho Kyoung
Miyake, Kentaro
Singh, Arun S.
Nelson, Scott D.
Dry, Sarah M.
Li, Yunfeng
Hiroshima, Yukihiko
Lwin, Thinzar M.
DeLong, Jonathan C.
Chishima, Takashi
Tanaka, Kuniya
Bouvet, Michael
Endo, Itaru
Eilber, Fritz C.
Hoffman, Robert M.
ONCOTARGET, 2017, 8 (22) : 35630 - 35638
[50] The advantages of patient derived orthotopic xenograft (PDOX) of cervical cancer compared to the PDX model
Hiroshima, Yukihiko
Zhang, Yong
Maawy, Ali
Sato, Sho
Murakami, Takashi
Yamamoto, Mako
Uehara, Fuminari
Miwa, Shinji
Yano, Shuya
Momiyama, Masashi
Chishima, Takashi
Tanaka, Kuniya
Bouvet, Michael
Endo, Itaru
Hoffman, Robert M.
CLINICAL & EXPERIMENTAL METASTASIS, 2015, 32 (03) : 208 - 208

← 1 2 3 4 5 →