Fluorescent humanized anti-CEA antibody specifically labels metastatic pancreatic cancer in a patient-derived orthotopic xenograft (PDOX) mouse model

被引：0
|
作者：
Lwin, Thinzar M. [1 ]
Miyake, Kentaro [1 ,2 ,3 ]
Murakami, Takashi [1 ,2 ,3 ]
DeLong, Jonathan C. [1 ]
Yazaki, Paul J. [4 ]
Shivley, John E. [4 ]
Clary, Bryan [1 ]
Hoffman, Robert M. [1 ,2 ]
Bouvet, Michael [1 ,5 ]
机构：
[1] Univ Calif San Diego, Dept Surg, San Diego, CA 92103 USA
[2] AntiCanc Inc, San Diego, CA USA
[3] Yokohama City Univ, Grad Sch Med, Dept Gastroenterol Surg, Yokohama, Kanagawa, Japan
[4] City Hope Natl Med Ctr, 1500 E Duarte Rd, Duarte, CA 91010 USA
[5] VA San Diego Healthcare Syst, San Diego, CA USA
来源：
MOLECULAR-GUIDED SURGERY: MOLECULES, DEVICES, AND APPLICATIONS IV | 2018年 / 10478卷
关键词：
Fluorescence-guided-surgery; LICOR IRDye800CW; Anti-CEA antibody; Patient derived orthotopic xenograft Model; Pancreatic cancer; In-Situ tumor visualization; Fluorescence imaging; Tumor specific fluorescence; GUIDED SURGERY; MARGIN STATUS; RESECTION; PANCREATICODUODENECTOMY; IMPACT;
D O I：
10.1117/12.2292546
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Specific tumor targeting can result in selective labeling of cancer in vivo for surgical navigation. In the present study, we show that the use of an anti-CEA antibody conjugated to the near-infrared (NIR) fluorescent dye, IRDye800CW, can selectively target and label pancreatic cancer and its metastases in a clinically relevant patient derived xenograft mouse model.
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页数：10
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