Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes

被引：121
|
作者：
McBean, Gethin J. [1 ]
机构：
[1] Univ Coll Dublin, Conway Inst, Sch Biomol & Biomed Sci, Dublin, Ireland
来源：
ANTIOXIDANTS | 2017年 / 6卷 / 03期
关键词：
cysteine; cystine; cysteamine; cystathionine; glutathione; x(c)(-) cystine-glutamate exchanger; transsulfuration; CYSTATHIONINE BETA-SYNTHASE; HYDROGEN-SULFIDE; SYSTEM X(C)(-); OXIDATIVE STRESS; TRANSSULFURATION PATHWAY; CYSTINE/GLUTAMATE ANTIPORTER; TRANSPORT-SYSTEM; UP-REGULATION; NITRIC-OXIDE; GAMMA-LYASE;
D O I：
10.3390/antiox6030062
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review discusses the current understanding of cysteine and glutathione redox balance in astrocytes. Particular emphasis is placed on the impact of oxidative stress and astrocyte activation on pathways that provide cysteine as a precursor for glutathione. The effect of the disruption of thiol-containing amino acid metabolism on the antioxidant capacity of astrocytes is also discussed.
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页数：13
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