Protein Engineering in the 21st Century

被引：10

作者：

Chica, Roberto A. ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ottawa, ON K1N 6N5, Canada

来源：

PROTEIN SCIENCE | 2015年 / 24卷 / 04期

关键词：

Protein folding; Protein NMR; Enzymes; Computational protein design; Protein-peptide interactions;

D O I：

10.1002/pro.2656

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：431 / 433

页数：3

共 14 条

[1] Severing of a hydrogen bond disrupts amino acid networks in the catalytically active state of the alpha subunit of tryptophan synthase [J].

Axe, Jennifer M. ;

O'Rourke, Kathleen F. ;

Kerstetter, Nicole E. ;

Yezdimer, Eric M. ;

Chan, Yan M. ;

Chasin, Alexander ;

Boehr, David D. .

PROTEIN SCIENCE, 2015, 24 (04) :484-494

[2] Computer-aided design of a catalyst for Edman degradation utilizing substrate-assisted catalysis [J].

Borgo, Benjamin ;

Havranek, James J. .

PROTEIN SCIENCE, 2015, 24 (04) :571-579

[3] Protein unfolding rates correlate as strongly as folding rates with native structure [J].

Broom, Aron ;

Gosavi, Shachi ;

Meiering, Elizabeth M. .

PROTEIN SCIENCE, 2015, 24 (04) :580-587

[4] Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets [J].

Clinton, Tracy R. ;

Weinstock, Matthew T. ;

Jacobsen, Michael T. ;

Szabo-Fresnais, Nicolas ;

Pandya, Maya J. ;

Whitby, Frank G. ;

Herbert, Andrew S. ;

Prugar, Laura I. ;

McKinnon, Rena ;

Hill, Christopher P. ;

Welch, Brett D. ;

Dye, John M. ;

Eckert, Debra M. ;

Kay, Michael S. .

PROTEIN SCIENCE, 2015, 24 (04) :446-463

[5] Optimization of rotamers prior to template minimization improves stability predictions made by computational protein design [J].

Davey, James A. ;

Chica, Roberto A. .

PROTEIN SCIENCE, 2015, 24 (04) :545-560

[6] Asymmetric mutations in the tetrameric R67 dihydrofolate reductase reveal high tolerance to active-site substitutions [J].

Ebert, Maximilian C. C. J. C. ;

Morley, Krista L. ;

Volpato, Jordan P. ;

Schmitzer, Andreea R. ;

Pelletier, Joelle N. .

PROTEIN SCIENCE, 2015, 24 (04) :495-507

[7] Combinatorial active-site variants confer sustained clavulanate resistance in BlaC β-lactamase from Mycobacterium tuberculosis [J].

Egesborg, Philippe ;

Carlettini, Helene ;

Volpato, Jordan P. ;

Doucet, Nicolas .

PROTEIN SCIENCE, 2015, 24 (04) :534-544

[8] Influence of hydrophobic mismatch on the catalytic activity of Escherichia coli GlpG rhomboid protease [J].

Foo, Alexander C. Y. ;

Harvey, Brandon G. R. ;

Metz, Jeff J. ;

Goto, Natalie K. .

PROTEIN SCIENCE, 2015, 24 (04) :464-473

[9] Vibrational entropy differences between mesophile and thermophile proteins and their use in protein engineering [J].

Frappier, Vincent ;

Najmanovich, Rafael .

PROTEIN SCIENCE, 2015, 24 (04) :474-483

[10] Network of long-range concerted chemical shift displacements upon ligand binding to human angiogenin [J].

Gagne, Donald ;

Narayanan, Chitra ;

Doucet, Nicolas .

PROTEIN SCIENCE, 2015, 24 (04) :525-533

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