Disintegration-controllable stimuli-responsive polyelectrolyte multilayer microcapsules via covalent layer-by-layer assembly

被引：28
作者：
Mu, Bin
Lu, Chunyin
Liu, Peng [1 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2011年 / 82卷 / 02期
关键词：
Multi layer microcapsule; Stimuli-responsive; Covalent layer-by-layer assembly; Disintegration-controllable; IONIC-STRENGTH; CAPSULES; NANOPARTICLES; ALGINATE; CHITOSAN; MICROSPHERES; NANOCAPSULES; TEMPERATURE; PARTICLES; HYDROGELS;
D O I：
10.1016/j.colsurfb.2010.09.024
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The disintegration-controllable stimuli-responsive polyelectrolyte multilayer microcapsules have been fabricated via the covalent layer-by-layer assembly between the amino groups of chitosan (CS) and the aldehyde groups of the oxidized sodium alginate (USA) onto the sacrificial templates (polystyrene sulfonate, PSS) which was removed by dialysis subsequently. The covalent crosslinking bonds of the multilayer microcapsules were confirmed by FTIR analysis. The TEM analysis showed that the diameter of the multilayer microcapsules was <200 nm. The diameter of the multilayer microcapsules decreased with the increasing of the pH values or the ionic strength. The pH and ionic strength dual-responsive multilayer microcapsules were stable in acidic and neutral media while they could disintegrate only at strong basic media. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：385 / 390
页数：6
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