Synthesis of functionally substituted unsymmetrical biaryls via a novel double metal catalyzed coupling reaction

被引：48

作者：

Miller, JA ^{[1
]}

Farrell, RP ^{[1
]}

机构：

[1] Catalyt Pharmaceut, Mt View, CA 94043 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 40期

关键词：

D O I：

10.1016/S0040-4039(98)01587-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Unsymmetrical biaryls containing "reactive" functional groups (e.g., nitrile or eater groups) can be synthesized in an efficient manner by the direct Ni- or Pd-catalyzed coupling of aryl halides (X = Cl, Br, I) with aryl Grignard (or -lithium) reagents, provided that a catalytic amount of a Zn or Cd salt is also present. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7275 / 7278

页数：4

共 4 条

[1] SELECTIVE CARBON-CARBON BOND FORMATION VIA TRANSITION-METAL CATALYSIS .3. HIGHLY SELECTIVE SYNTHESIS OF UNSYMMETRICAL BIARYLS AND DIARYLMETHANES BY NICKEL-CATALYZED OR PALLADIUM-CATALYZED REACTION OF ARYL DERIVATIVES AND BENZYLZINC DERIVATIVES WITH ARYL HALIDES [J].