Cardiovascular Drugs and Osteoarthritis: Effects of Targeting Ion Channels

被引:19
作者
Vaiciuleviciute, Raminta [1 ]
Bironaite, Daiva [1 ]
Uzieliene, Ilona [1 ]
Mobasheri, Ali [1 ,2 ,3 ,4 ,5 ,6 ]
Bernotiene, Eiva [1 ]
机构
[1] State Res Inst, Ctr Innovat Med, Dept Regenerat Med, LT-08406 Vilnius, Lithuania
[2] Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol, FI-90014 Oulu, Finland
[3] Univ Med Ctr Utrecht, Dept Orthoped, NL-508 GA Utrecht, Netherlands
[4] Univ Med Ctr Utrecht, Dept Rheumatol, NL-508 GA Utrecht, Netherlands
[5] Univ Med Ctr Utrecht, Dept Clin Immunol, NL-508 GA Utrecht, Netherlands
[6] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Joint Surg, Guangzhou 510080, Peoples R China
关键词
osteoarthritis; cardiovascular drugs; hypertension; vascular dysfunction; cartilage; chondrocyte; ion channels; CONVERTING ENZYME-INHIBITOR; GROWTH-PLATE CHONDROCYTES; INFRAPATELLAR FAT PAD; KNEE OSTEOARTHRITIS; OXIDATIVE STRESS; SUBCHONDRAL BONE; GENE-EXPRESSION; CHONDROGENIC DIFFERENTIATION; ENDOTHELIAL DYSFUNCTION; ARTICULAR CHONDROCYTES;
D O I
10.3390/cells10102572
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Osteoarthritis (OA) and cardiovascular diseases (CVD) share many similar features, including similar risk factors and molecular mechanisms. A great number of cardiovascular drugs act via different ion channels and change ion balance, thus modulating cell metabolism, osmotic responses, turnover of cartilage extracellular matrix and inflammation. These drugs are consumed by patients with CVD for many years; however, information about their effects on the joint tissues has not been fully clarified. Nevertheless, it is becoming increasingly likely that different cardiovascular drugs may have an impact on articular tissues in OA. Here, we discuss the potential effects of direct and indirect ion channel modulating drugs, including inhibitors of voltage gated calcium and sodium channels, hyperpolarization-activated cyclic nucleotide-gated channels, beta-adrenoreceptor inhibitors and angiotensin-aldosterone system affecting drugs. The aim of this review was to summarize the information about activities of cardiovascular drugs on cartilage and subchondral bone and to discuss their possible consequences on the progression of OA, focusing on the modulation of ion channels in chondrocytes and other joint cells, pain control and regulation of inflammation. The implication of cardiovascular drug consumption in aetiopathogenesis of OA should be considered when prescribing ion channel modulators, particularly in long-term therapy protocols.
引用
收藏
页数:23
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