Pluripotency of Stem Cells from Human Exfoliated Deciduous Teeth for Tissue Engineering

被引：61

作者：

Rosa, Vinicius ^{[1
]}

Dubey, Nileshkumar ^{[1
]}

Islam, Intekhab ^{[2
]}

Min, Kyung-San ^{[3
]}

Nor, Jacques E. ^{[4
]}

机构：

[1] Natl Univ Singapore, Fac Dent, Oral Sci, Singapore 119083, Singapore

[2] Natl Univ Singapore, Fac Dent, Discipline Oral & Maxillofacial Surg, Singapore 119083, Singapore

[3] Chonbuk Natl Univ, Sch Dent, Dept Conservat Dent, Jeonju 54596, South Korea

[4] Univ Michigan, Sch Dent, Dept Cariol Restorat Sci & Endodont, Ann Arbor, MI 48109 USA

来源：

STEM CELLS INTERNATIONAL | 2016年 / 2016卷

基金：

英国医学研究理事会;

关键词：

HUMAN DENTAL-PULP; CRANIAL NEURAL CREST; IN-VITRO; TOOTH; DIFFERENTIATION; REGENERATION; CAPACITY; RECOVERY; SERUM;

D O I：

10.1155/2016/5957806

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Stem cells from human exfoliated deciduous teeth (SHED) are highly proliferative pluripotent cells that can be retrieved from primary teeth. Although SHED are isolated from the dental pulp, their differentiation potential is not limited to odontoblasts only. In fact, SHED can differentiate into several cell types including neurons, osteoblasts, adipocytes, and endothelial cells. The high plasticity makes SHED an interesting stem cell model for research in several biomedical areas. This review will discuss key findings about the characterization and differentiation of SHED into odontoblasts, neurons, and hormone secreting cells (e.g., hepatocytes and islet-like cell aggregates). The outcomes of the studies presented here support the multipotency of SHED and their potential to be used for tissue engineering-based therapies.

引用

页数：6

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